| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | How to Train Your Dragon | $1,630,412 | - | 488 | - | $3,341 | $1,630,412 | 1 | Universal Pictures International (UPI) | true | false |
| 2 | 1 | Alice in Wonderland | $1,569,904 | -63.6% | 409 | -180 | $3,838 | $36,680,575 | 4 | Walt Disney Pictures | false | false |
| 3 | - | Happy Family | $1,483,181 | - | 353 | - | $4,201 | $1,483,181 | 1 | 01 Distribution | true | false |
| 4 | 2 | Loose Cannons | $1,096,026 | -47.6% | 333 | -90 | $3,291 | $7,960,574 | 3 | 01 Distribution | false | false |
| 5 | - | Remember Me | $1,037,031 | - | 335 | - | $3,095 | $1,043,442 | 1 | Eagle Pictures | true | false |
| 6 | 3 | It's Complicated | $934,728 | -43.8% | 293 | -9 | $3,190 | $3,218,113 | 2 | United International Pictures | false | false |
| 7 | 4 | Shutter Island | $524,720 | -53.5% | 158 | -98 | $3,321 | $8,175,323 | 4 | Medusa Distribuzione | false | false |
| 8 | 5 | Percy Jackson & the Olympians: The Lightning Thief | $360,035 | -66.9% | 196 | -91 | $1,836 | $3,626,171 | 3 | 20th Century Fox International | false | false |
| 9 | - | Daybreakers | $341,457 | - | 146 | - | $2,338 | $341,457 | 1 | Sony Pictures Releasing | true | false |
| 10 | 6 | Edge of Darkness | $310,137 | -64.4% | 182 | -90 | $1,704 | $1,454,942 | 2 | 01 Distribution | false | false |
| 11 | 7 | Tutto l'amore del mondo | $167,264 | -76.1% | 163 | -105 | $1,026 | $1,081,500 | 2 | Medusa Distribuzione | false | false |
| 12 | 9 | Invictus | $155,599 | -61.4% | 76 | -54 | $2,047 | $8,041,341 | 5 | Warner Bros. | false | false |
| 13 | 8 | Genitori & figli:) - Agitare bene prima dell'uso | $146,535 | -74% | 83 | -119 | $1,765 | $11,036,701 | 5 | Filmauro | false | false |
| 14 | 12 | A Prophet | $130,696 | -42.2% | 79 | -2 | $1,654 | $449,233 | 2 | BIM Distribuzione | false | false |
| 15 | 14 | The Concert | $88,606 | -45% | 33 | -14 | $2,685 | $4,099,929 | 8 | BIM Distribuzione | false | false |
| 16 | 10 | Avatar | $81,574 | -79.2% | 26 | -47 | $3,137 | $86,981,788 | 11 | 20th Century Fox International | false | false |
| 17 | 17 | I Am Love | $72,405 | +6% | 42 | +36 | $1,723 | $164,997 | 2 | Mikado Film | false | false |
| 18 | 15 | La valigia sul letto | $48,139 | -60.4% | 20 | -19 | $2,406 | $545,307 | 3 | Medusa Distribuzione | false | false |
| 19 | 11 | Valentine's Day | $46,449 | -86.8% | 33 | -184 | $1,407 | $1,846,603 | 3 | Warner Bros. | false | false |
| 20 | 16 | Women Without Men | $35,608 | -51.2% | 24 | -9 | $1,483 | $289,082 | 3 | BIM Distribuzione | false | false |
