| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Alice in Wonderland | $18,582 | -17.7% | 6 | - | $3,097 | $169,960 | 4 | Walt Disney Pictures | false | false |
| 2 | 4 | Avatar | $9,801 | -3.8% | 14 | - | $700 | $1,287,920 | 15 | 20th Century Fox International | false | false |
| 3 | 3 | Shutter Island | $8,059 | -21.8% | 4 | - | $2,014 | $95,709 | 3 | United International Pictures | false | false |
| 4 | - | Edge of Darkness | $7,366 | - | 5 | - | $1,473 | $8,399 | 1 | N/A | true | false |
| 5 | 2 | The Book of Eli | $7,031 | -40.6% | 6 | - | $1,171 | $23,512 | 2 | Sony Pictures Releasing | false | false |
| 6 | - | The Rebound | $6,578 | - | 5 | - | $1,315 | $7,199 | 1 | N/A | true | false |
| 7 | 6 | The Men Who Stare at Goats | $2,418 | -14.9% | 4 | - | $604 | $22,758 | 3 | N/A | false | false |
| 8 | 5 | The Wolfman | $2,004 | -35.4% | 6 | - | $334 | $87,624 | 5 | United International Pictures | false | false |
| 9 | 7 | Percy Jackson & the Olympians: The Lightning Thief | $1,557 | -34.4% | 7 | - | $222 | $38,748 | 5 | 20th Century Fox International | false | false |
| 10 | 8 | The Imaginarium of Doctor Parnassus | $1,547 | -22.1% | 2 | - | $773 | $37,939 | 7 | N/A | false | false |
| 11 | 10 | Valentine's Day | $1,496 | -17.4% | 6 | - | $249 | $127,684 | 7 | Warner Bros. | false | false |
| 12 | 9 | The Princess and the Frog | $1,290 | -29.5% | 6 | - | $215 | $67,892 | 9 | Walt Disney Pictures | false | false |
| 13 | - | A Serious Man | $729 | - | 1 | - | $729 | $15,019 | 1 | N/A | true | false |
| 14 | 15 | Toy Story 2009 Re-release | $724 | +16.4% | 3 | - | $241 | $29,830 | 7 | Walt Disney Pictures | false | false |
| 15 | 13 | Alvin and the Chipmunks: The Squeakquel | $673 | -6.5% | 6 | - | $112 | $59,040 | 11 | 20th Century Fox International | false | false |
| 16 | 11 | Arthur and the Revenge of Maltazard | $599 | -40.3% | 6 | - | $99 | $62,960 | 13 | N/A | false | false |
| 17 | 14 | Sherlock Holmes | $478 | -32.7% | 6 | - | $79 | $223,413 | 12 | Warner Bros. | false | false |
| 18 | 17 | Antichrist | $222 | -34.5% | 1 | - | $222 | $12,832 | 4 | N/A | false | false |
| 19 | 18 | Daybreakers | $204 | -36.6% | 2 | - | $102 | $2,704 | 3 | N/A | false | false |
| 20 | 19 | Nine | $184 | -34.3% | 4 | - | $46 | $31,463 | 8 | N/A | false | false |
| 21 | 22 | Pope Joan | $181 | -1.6% | 2 | - | $90 | $9,135 | 4 | N/A | false | false |
| 22 | 23 | The Lovely Bones | $172 | -4.4% | 5 | - | $34 | $27,351 | 6 | United International Pictures | false | false |
| 23 | 25 | Garfield's Fun Fest | $137 | -1.4% | 2 | - | $68 | $13,935 | 14 | N/A | false | false |
| 24 | 20 | Baaria | $122 | -50.4% | 1 | - | $122 | $14,599 | 3 | N/A | false | false |
| 25 | 30 | Law Abiding Citizen | $103 | +164.1% | 5 | - | $20 | $20,898 | 6 | N/A | false | false |
| 26 | 16 | Did You Hear About the Morgans? | $102 | -79.3% | 1 | -4 | $102 | $87,635 | 10 | Sony Pictures Releasing | false | false |
| 27 | 12 | Invictus 2010 Re-release | $63 | -92.7% | 4 | - | $15 | $25,393 | 4 | Warner Bros. | false | false |
| 28 | 28 | Don't Look Back | $14 | -80% | 2 | - | $7 | $13,084 | 5 | N/A | false | false |
| 29 | 21 | Up in the Air | $4 | -97.8% | 5 | - | $0 | $45,574 | 8 | United International Pictures | false | false |
