| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Alice in Wonderland | $679,079 | +49.6% | 131 | +3 | $5,183 | $6,977,857 | 5 | Walt Disney Pictures | false | false |
| 2 | 2 | How to Train Your Dragon | $540,591 | +34% | 127 | +9 | $4,256 | $1,004,166 | 2 | Paramount Pictures International | false | false |
| 3 | 3 | Shutter Island | $207,003 | +16.1% | 45 | +2 | $4,600 | $1,170,256 | 4 | Paramount Pictures International | false | false |
| 4 | - | The Bounty Hunter | $177,129 | - | 43 | - | $4,119 | $177,129 | 1 | Sony Pictures Releasing | true | false |
| 5 | 4 | The Book of Eli | $104,160 | +11.8% | 41 | - | $2,540 | $474,508 | 3 | Sony Pictures Releasing | false | false |
| 6 | - | The Fourth Kind | $78,774 | - | 25 | - | $3,150 | $78,774 | 1 | Alfa Films | true | false |
| 7 | 6 | Edge of Darkness | $56,034 | +0.5% | 56 | -8 | $1,000 | $1,086,557 | 6 | Warner Bros. | false | false |
| 8 | 8 | The Blind Side | $46,165 | +13.2% | 33 | +1 | $1,398 | $219,263 | 3 | Warner Bros. | false | false |
| 9 | - | Fame | $44,121 | - | 37 | - | $1,192 | $44,121 | 1 | Impacto Cine | true | false |
| 10 | 5 | Brothers | $31,329 | -49.5% | 34 | - | $921 | $108,455 | 2 | Distribution Company | false | false |
| 11 | - | Seraphine | $30,555 | - | 8 | - | $3,819 | $30,555 | 1 | N/A | true | false |
| 12 | 11 | The Hurt Locker | $22,826 | -23.7% | 43 | -6 | $530 | $781,478 | 9 | Distribution Company | false | false |
| 13 | 7 | The Rebound | $21,936 | -59.7% | 28 | +2 | $783 | $91,288 | 2 | Alfa Films | false | false |
| 14 | 14 | Avatar | $20,025 | +78% | 10 | -6 | $2,002 | $13,372,233 | 14 | 20th Century Fox International | false | false |
| 15 | 10 | Everybody's Fine | $19,958 | -34% | 22 | -6 | $907 | $159,154 | 3 | Walt Disney Pictures | false | false |
| 16 | 9 | Paco | $19,506 | -40.9% | 20 | -20 | $975 | $163,808 | 3 | Primer Plano Film Group | false | false |
| 17 | 12 | Did You Hear About the Morgans? | $15,559 | -31.2% | 25 | +1 | $622 | $270,980 | 4 | Sony Pictures Releasing | false | false |
| 18 | 13 | Couples Retreat | $6,925 | -50.8% | 13 | -2 | $532 | $142,782 | 5 | Universal Pictures International (UPI) | false | false |
| 19 | 16 | The Girl with the Dragon Tattoo | $6,896 | -31.6% | 14 | -1 | $492 | $270,529 | 7 | N/A | false | false |
| 20 | 17 | Bad Lieutenant: Port of Call New Orleans | $6,165 | -36.4% | 15 | -8 | $411 | $167,370 | 5 | Distribution Company | false | false |
| 21 | 19 | The Wolfman | $5,043 | -26.8% | 12 | -9 | $420 | $1,115,592 | 8 | Universal Pictures International (UPI) | false | false |
| 22 | 20 | The Secret in Their Eyes | $4,664 | -29.5% | 16 | -6 | $291 | $9,250,444 | 34 | Distribution Company | false | false |
| 23 | 18 | Precious | $4,488 | -36.5% | 10 | -4 | $448 | $282,943 | 8 | N/A | false | false |
| 24 | 22 | A Serious Man | $3,363 | -40% | 3 | -5 | $1,121 | $144,849 | 6 | Universal Pictures International (UPI) | false | false |
| 25 | 23 | Percy Jackson & the Olympians: The Lightning Thief | $3,023 | -40.7% | 15 | -10 | $201 | $721,653 | 7 | 20th Century Fox International | false | false |
| 26 | 27 | 9 | $2,724 | -25.8% | 14 | -4 | $194 | $35,479 | 3 | Distribution Company | false | false |
| 27 | 24 | Valentine's Day | $2,615 | -38.5% | 11 | -2 | $237 | $882,475 | 8 | Warner Bros. | false | false |
| 28 | 28 | Invictus | $1,975 | -39.2% | 6 | -11 | $329 | $980,406 | 10 | Warner Bros. | false | false |
| 29 | 21 | Crazy Heart | $1,791 | -70% | 8 | -3 | $223 | $94,983 | 4 | 20th Century Fox International | false | false |
| 30 | 26 | The Imaginarium of Doctor Parnassus | $1,650 | -59% | 4 | -4 | $412 | $242,463 | 6 | Sony Pictures Releasing | false | false |
| 31 | 25 | Our Beloved Month of August | $1,600 | -62.3% | 3 | -1 | $533 | $37,431 | 5 | N/A | false | false |
| 32 | 41 | Birds of Paradise | $1,560 | +590.3% | 5 | - | $312 | $191,277 | 7 | Sony Pictures Releasing | false | false |
| 33 | 30 | The Princess and the Frog | $1,341 | +13.5% | 8 | +1 | $167 | $1,919,916 | 13 | Walt Disney Pictures | false | false |
| 34 | 29 | Old Dogs | $1,091 | -14.2% | 6 | -4 | $181 | $1,505,108 | 11 | Walt Disney Pictures | false | false |
| 35 | 48 | Tooth Fairy | $701 | +7,688.9% | 3 | +2 | $233 | $480,940 | 9 | 20th Century Fox International | false | false |
| 36 | 40 | An Education | $700 | +204.3% | 2 | -1 | $350 | $186,751 | 9 | Sony Pictures Releasing | false | false |
| 37 | 38 | Zombieland | $687 | +177% | 2 | +1 | $343 | $106,939 | 10 | Sony Pictures Releasing | false | false |
| 38 | 34 | Alvin and the Chipmunks: The Squeakquel | $672 | +2.4% | 4 | -1 | $168 | $1,088,077 | 11 | 20th Century Fox International | false | false |
| 39 | 36 | Astro Boy | $648 | +43.7% | 10 | +6 | $64 | $174,198 | 10 | Alfa Films | false | false |
| 40 | 46 | Up in the Air | $561 | +371.4% | 2 | +1 | $280 | $720,992 | 11 | Paramount Pictures International | false | false |
| 41 | 35 | Mongol: The Rise of Genghis Khan | $557 | +3.3% | 1 | -1 | $557 | $9,137 | 4 | Alfa Films | false | false |
| 42 | 15 | Coco 2010 Re-release | $297 | -97.2% | 2 | -7 | $148 | $13,533 | 2 | Impacto Cine | false | false |
| 43 | 42 | Daybreakers | $197 | - | 1 | - | $197 | $388,845 | 11 | Distribution Company | false | false |
| 44 | 45 | Inglourious Basterds | $124 | -4.6% | 1 | - | $124 | $1,216,394 | 31 | Universal Pictures International (UPI) | false | false |
| 45 | 32 | The Young Victoria | $93 | -89.4% | 1 | -2 | $93 | $182,531 | 12 | Distribution Company | false | false |
| 46 | - | Nine | $54 | - | 1 | - | $54 | $267,496 | 10 | Sony Pictures Releasing | false | false |
| 47 | 47 | Broken Embraces | $53 | -51.4% | 1 | - | $53 | $515,741 | 27 | Universal Pictures International (UPI) | false | false |
| 48 | 43 | Nora's Will | $2 | -99% | 1 | - | $2 | $53,724 | 10 | Primer Plano Film Group | false | false |
