| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | How to Train Your Dragon | $373,398 | +31.7% | 69 | +3 | $5,411 | $727,350 | 2 | United International Pictures | false | false |
| 2 | 2 | Legion | $121,112 | +6.7% | 26 | - | $4,658 | $277,006 | 2 | Sony Pictures Releasing | false | false |
| 3 | - | Edge of Darkness | $78,681 | - | 30 | - | $2,622 | $78,681 | 1 | Warner Bros. | true | false |
| 4 | 4 | Avatar | $46,182 | +50.4% | 34 | +11 | $1,358 | $10,353,872 | 16 | 20th Century Fox International | false | false |
| 5 | - | Daybreakers | $29,201 | - | 16 | - | $1,825 | $29,201 | 1 | N/A | true | false |
| 6 | 3 | The Hurt Locker | $26,884 | -16.9% | 18 | -1 | $1,493 | $324,145 | 7 | N/A | false | false |
| 7 | - | The Men Who Stare at Goats | $18,526 | - | 9 | - | $2,058 | $18,526 | 1 | Sony Pictures Releasing | true | false |
| 8 | 6 | Percy Jackson & the Olympians: The Lightning Thief | $18,100 | -19.7% | 24 | -6 | $754 | $781,847 | 8 | 20th Century Fox International | false | false |
| 9 | 7 | The Blind Side | $17,154 | -14% | 7 | -1 | $2,450 | $75,992 | 3 | Warner Bros. | false | false |
| 10 | 5 | The Box | $15,883 | -33.1% | 18 | +1 | $882 | $48,900 | 2 | N/A | false | false |
| 11 | 8 | 500 Days of Summer | $15,785 | -10.2% | 6 | -2 | $2,630 | $101,112 | 4 | 20th Century Fox International | false | false |
| 12 | 9 | [Rec]² | $13,508 | -10.8% | 13 | -3 | $1,039 | $78,984 | 3 | N/A | false | false |
| 13 | 14 | Let the Right One In | $13,381 | +51.4% | 5 | - | $2,676 | $25,537 | 2 | N/A | false | false |
| 14 | 11 | Alvin and the Chipmunks: The Squeakquel | $11,561 | -11.1% | 18 | -4 | $642 | $1,402,101 | 10 | 20th Century Fox International | false | false |
| 15 | 15 | The Haunting in Connecticut | $10,518 | +98.4% | 4 | - | $2,629 | $191,776 | 12 | Transeuropa | false | false |
| 16 | 13 | The Lovely Bones | $8,897 | -19.1% | 11 | -3 | $808 | $268,419 | 7 | United International Pictures | false | false |
| 17 | 12 | My Best Friend's Girl | $5,937 | -51.5% | 6 | -8 | $989 | $55,618 | 3 | Transeuropa | false | false |
| 18 | 10 | The Wolfman | $4,752 | -68.2% | 10 | -16 | $475 | $760,079 | 8 | United International Pictures | false | false |
| 19 | 17 | Halloween II | $3,513 | -6.8% | 7 | +1 | $501 | $60,383 | 4 | N/A | false | false |
| 20 | 22 | Invictus | $2,557 | +149% | 6 | +3 | $426 | $202,089 | 9 | Warner Bros. | false | false |
| 21 | 16 | Valentine's Day | $2,453 | -41.6% | 3 | -1 | $817 | $320,311 | 8 | Warner Bros. | false | false |
| 22 | 18 | Up in the Air | $2,302 | -37.9% | 2 | - | $1,151 | $150,563 | 9 | United International Pictures | false | false |
| 23 | 28 | Nine | $2,053 | +702% | 4 | +3 | $513 | $50,878 | 7 | Sony Pictures Releasing | false | false |
| 24 | 21 | The Imaginarium of Doctor Parnassus | $2,001 | +20.5% | 3 | - | $667 | $88,777 | 10 | Sony Pictures Releasing | false | false |
| 25 | 19 | Precious | $1,962 | +11.5% | 2 | +1 | $981 | $45,371 | 6 | N/A | false | false |
| 26 | 20 | Ponyo | $1,501 | -14.2% | 6 | - | $250 | $35,934 | 6 | Andes Films | false | false |
| 27 | 24 | Everybody's Fine | $1,049 | +45.3% | 3 | -1 | $349 | $31,373 | 6 | Walt Disney Pictures | false | false |
| 28 | 23 | Welcome to the Sticks | $584 | -34.7% | 1 | - | $584 | $26,681 | 4 | N/A | false | false |
| 29 | 29 | An Education | $223 | +16.1% | 1 | -1 | $223 | $26,998 | 11 | Sony Pictures Releasing | false | false |
