| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Alice in Wonderland | $517,067 | -4.2% | 133 | -9 | $3,887 | $6,097,516 | 5 | Walt Disney Pictures | false | false |
| 2 | 2 | How to Train Your Dragon | $382,546 | +11% | 115 | +7 | $3,326 | $1,140,355 | 2 | United International Pictures | false | false |
| 3 | 3 | The Book of Eli | $153,668 | +0.9% | 75 | - | $2,048 | $785,299 | 3 | Sony Pictures Releasing | false | false |
| 4 | 4 | The Blind Side | $84,497 | -8.8% | 46 | -1 | $1,836 | $267,086 | 2 | Warner Bros. | false | false |
| 5 | 5 | Did You Hear About the Morgans? | $70,615 | -12.5% | 50 | - | $1,412 | $230,105 | 2 | Sony Pictures Releasing | false | false |
| 6 | 9 | Avatar | $50,586 | +65.5% | 12 | +3 | $4,215 | $13,586,976 | 16 | 20th Century Fox International | false | false |
| 7 | 6 | Shutter Island | $50,417 | +9.2% | 25 | -2 | $2,016 | $383,587 | 4 | United International Pictures | false | false |
| 8 | 7 | Remember Me | $39,781 | -0.5% | 30 | - | $1,326 | $125,648 | 2 | Cine Colombia | false | false |
| 9 | 8 | Edge of Darkness | $31,326 | -0.2% | 37 | - | $846 | $420,255 | 4 | Warner Bros. | false | false |
| 10 | 12 | Percy Jackson & the Olympians: The Lightning Thief | $11,725 | +31.7% | 22 | - | $532 | $862,503 | 8 | 20th Century Fox International | false | false |
| 11 | 10 | The Hurt Locker | $10,946 | +3.2% | 10 | -1 | $1,094 | $232,356 | 8 | Cineplex | false | false |
| 12 | 11 | [Rec]² | $10,565 | +12% | 10 | - | $1,056 | $234,644 | 5 | Cine Colombia | false | false |
| 13 | 14 | Tooth Fairy | $9,661 | +71.2% | 19 | -1 | $508 | $1,130,390 | 11 | 20th Century Fox International | false | false |
| 14 | 17 | Old Dogs | $6,353 | +121.9% | 6 | - | $1,058 | $1,178,446 | 13 | Walt Disney Pictures | false | false |
| 15 | 13 | The Anarchist's Wife | $6,207 | +9.1% | 4 | - | $1,551 | $18,012 | 2 | Cineplex | false | false |
| 16 | 16 | The Wolfman | $5,539 | +30.8% | 4 | - | $1,384 | $1,042,258 | 8 | United International Pictures | false | false |
| 17 | 15 | Couples Retreat | $4,530 | -0.9% | 4 | -1 | $1,132 | $216,579 | 6 | United International Pictures | false | false |
| 18 | 18 | Everybody's Fine | $3,465 | +30.4% | 14 | +1 | $247 | $62,988 | 4 | Walt Disney Pictures | false | false |
| 19 | 19 | Law Abiding Citizen | $2,362 | -4.6% | 3 | +1 | $787 | $277,900 | 6 | Cineplex | false | false |
| 20 | 20 | Precious | $2,340 | -4.3% | 5 | - | $468 | $297,301 | 7 | Cine Colombia | false | false |
| 21 | 22 | The Imaginarium of Doctor Parnassus | $2,261 | +41% | 2 | - | $1,130 | $64,733 | 5 | Sony Pictures Releasing | false | false |
| 22 | 23 | The White Ribbon | $1,816 | +26.7% | 2 | -2 | $908 | $31,470 | 5 | - | false | false |
| 23 | 21 | Invictus | $1,730 | +5.2% | 7 | - | $247 | $400,498 | 9 | Warner Bros. | false | false |
| 24 | 24 | A Prophet | $1,661 | +36.4% | 3 | - | $553 | $12,336 | 3 | Sony Pictures Releasing | false | false |
| 25 | 25 | A Serious Man | $1,171 | +13.9% | 2 | - | $585 | $9,863 | 3 | United International Pictures | false | false |
| 26 | 26 | Alvin and the Chipmunks: The Squeakquel | $1,130 | +49.1% | 7 | - | $161 | $1,398,967 | 14 | 20th Century Fox International | false | false |
| 27 | 27 | The Men Who Stare at Goats | $739 | +9.6% | 1 | - | $739 | $12,001 | 4 | Sony Pictures Releasing | false | false |
