| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Nanny McPhee Returns | $3,854,967 | - | 512 | - | $7,529 | $3,854,967 | 1 | Universal Pictures International (UPI) | true | false |
| 2 | 1 | Alice in Wonderland | $3,720,713 | -48.9% | 510 | -15 | $7,295 | $51,887,854 | 4 | Walt Disney Pictures | false | false |
| 3 | - | The Blind Side | $1,957,195 | - | 371 | - | $5,275 | $1,957,195 | 1 | Warner Bros. | true | false |
| 4 | 3 | Shutter Island | $1,708,234 | -37.3% | 418 | -1 | $4,086 | $11,441,172 | 3 | Paramount Pictures International | false | false |
| 5 | 2 | The Bounty Hunter | $1,482,305 | -52% | 393 | -1 | $3,771 | $5,826,436 | 2 | Sony Pictures Releasing | false | false |
| 6 | 5 | Green Zone | $694,183 | -54.8% | 345 | -74 | $2,012 | $7,379,539 | 3 | Universal Pictures International (UPI) | false | false |
| 7 | 6 | The Spy Next Door 2010 Re-release | $586,576 | -44.1% | 330 | -2 | $1,777 | $1,841,218 | 2 | Paramount Pictures International | false | false |
| 8 | 4 | I Love You Phillip Morris | $550,595 | -65.6% | 329 | -13 | $1,673 | $2,841,833 | 2 | Entertainment One | false | false |
| 9 | - | Shank | $415,645 | - | 86 | - | $4,833 | $415,645 | 1 | Revolver Entertainment | true | false |
| 10 | 7 | Avatar | $335,072 | -50% | 170 | -56 | $1,971 | $135,693,425 | 15 | 20th Century Fox International | false | false |
| 11 | 8 | The Girl with the Dragon Tattoo | $244,721 | -47.3% | 104 | -22 | $2,353 | $1,919,640 | 3 | Momentum Pictures | false | false |
| 12 | - | Perrier's Bounty | $160,430 | - | 90 | - | $1,782 | $160,430 | 1 | Optimum Releasing | true | false |
| 13 | 9 | Hachi: A Dog's Tale | $70,733 | -81.9% | 228 | +102 | $310 | $1,563,107 | 3 | Entertainment Film Distributors | false | false |
| 14 | 10 | The Princess and the Frog | $64,596 | -70.5% | 199 | -187 | $324 | $16,387,133 | 7 | Walt Disney Pictures | false | false |
| 15 | - | Lourdes | $58,882 | - | 18 | - | $3,271 | $58,882 | 1 | Artificial Eye | true | false |
