| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | How to Train Your Dragon | $361,498 | - | 90 | - | $4,016 | $361,498 | 1 | United International Pictures | true | false |
| 2 | 2 | Tooth Fairy | $224,142 | -17.8% | 64 | - | $3,502 | $646,201 | 2 | 20th Century Fox International | false | false |
| 3 | 1 | Alice in Wonderland | $204,669 | -49.8% | 76 | -15 | $2,693 | $2,394,833 | 4 | Walt Disney Pictures | false | false |
| 4 | 3 | The Blind Side | $142,879 | -23.4% | 53 | +1 | $2,695 | $453,765 | 2 | Warner Bros. | false | false |
| 5 | 4 | It's Complicated | $100,022 | -19.8% | 60 | -6 | $1,667 | $1,158,176 | 5 | United International Pictures | false | false |
| 6 | 5 | Shutter Island | $92,527 | -8.9% | 44 | -2 | $2,102 | $447,814 | 3 | United International Pictures | false | false |
| 7 | - | The Hurt Locker | $68,641 | - | 21 | - | $3,268 | $68,641 | 1 | NuMetro Distribution | true | false |
| 8 | - | Armored | $50,207 | - | 31 | - | $1,619 | $50,207 | 1 | Sony Pictures Releasing | true | false |
| 9 | 6 | The Book of Eli | $46,533 | -23.9% | 36 | -16 | $1,292 | $661,970 | 5 | Sony Pictures Releasing | false | false |
| 10 | 8 | Valentine's Day | $32,606 | -24.6% | 37 | -12 | $881 | $1,469,321 | 7 | NuMetro Distribution | false | false |
| 11 | 7 | Remember Me | $29,744 | -37% | 27 | -13 | $1,101 | $191,448 | 3 | NuMetro Distribution | false | false |
| 12 | 12 | Saw VI | $20,740 | -2.4% | 20 | - | $1,037 | $55,160 | 2 | N/A | false | false |
| 13 | 10 | Nine | $19,591 | -34.4% | 19 | -7 | $1,031 | $138,920 | 3 | Sony Pictures Releasing | false | false |
| 14 | 9 | Avatar | $18,960 | -46.3% | 11 | -2 | $1,723 | $7,535,260 | 15 | 20th Century Fox International | false | false |
| 15 | 11 | Percy Jackson & the Olympians: The Lightning Thief | $17,869 | -25.2% | 24 | -7 | $744 | $584,837 | 6 | 20th Century Fox International | false | false |
| 16 | - | The Last Station 2010 Re-release | $17,188 | - | 10 | - | $1,718 | $17,188 | 1 | Ster-Kinekor Pictures | true | false |
| 17 | 13 | The Spy Next Door 2010 Re-release | $14,614 | -21.4% | 18 | -6 | $811 | $588,580 | 8 | N/A | false | false |
| 18 | 16 | Everybody's Fine | $5,857 | -41.8% | 5 | -5 | $1,171 | $49,980 | 3 | Walt Disney Pictures | false | false |
| 19 | 17 | Up in the Air | $5,650 | -30% | 9 | -4 | $627 | $431,579 | 9 | United International Pictures | false | false |
| 20 | 18 | An Education | $4,311 | -43% | 5 | -3 | $862 | $170,739 | 9 | United International Pictures | false | false |
| 21 | 15 | The Box | $2,581 | -78.2% | 8 | -18 | $322 | $54,566 | 3 | Ster-Kinekor Pictures | false | false |
| 22 | 21 | The Wolfman | $2,400 | -11.4% | 6 | -8 | $400 | $473,328 | 7 | N/A | false | false |
| 23 | 20 | Jozi | $2,241 | -22.2% | 6 | -2 | $373 | $105,980 | 5 | United International Pictures | false | false |
| 24 | 23 | Skin | $465 | -74.8% | 3 | -3 | $155 | $145,154 | 10 | N/A | false | false |
