| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | How to Train Your Dragon | $223,352 | -40.2% | 67 | -2 | $3,333 | $995,053 | 3 | United International Pictures | false | false |
| 2 | - | Shutter Island | $185,028 | - | 35 | - | $5,286 | $187,097 | 1 | United International Pictures | true | false |
| 3 | 2 | Legion | $66,323 | -45.2% | 26 | - | $2,550 | $371,117 | 3 | Sony Pictures Releasing | false | false |
| 4 | 3 | Edge of Darkness | $38,260 | -51.4% | 28 | -2 | $1,366 | $134,206 | 2 | Warner Bros. | false | false |
| 5 | 4 | Avatar | $24,720 | -46.5% | 32 | -2 | $772 | $10,388,312 | 17 | 20th Century Fox International | false | false |
| 6 | - | My Life in Ruins | $14,800 | - | 15 | - | $986 | $14,800 | 1 | N/A | true | false |
| 7 | 11 | 500 Days of Summer | $11,758 | -25.5% | 7 | +1 | $1,679 | $115,848 | 5 | 20th Century Fox International | false | false |
| 8 | 6 | The Hurt Locker | $11,369 | -57.7% | 15 | -3 | $757 | $340,325 | 8 | N/A | false | false |
| 9 | 5 | Daybreakers | $10,979 | -62.4% | 15 | -1 | $731 | $48,087 | 2 | N/A | false | false |
| 10 | 9 | The Blind Side | $8,834 | -48.5% | 6 | -1 | $1,472 | $87,247 | 4 | Warner Bros. | false | false |
| 11 | 13 | Let the Right One In | $8,319 | -37.8% | 5 | - | $1,663 | $36,926 | 3 | N/A | false | false |
| 12 | 7 | The Men Who Stare at Goats | $8,053 | -56.5% | 8 | -1 | $1,006 | $31,054 | 2 | Sony Pictures Releasing | false | false |
| 13 | 12 | [Rec]² | $6,533 | -51.6% | 13 | - | $502 | $89,568 | 4 | N/A | false | false |
| 14 | 8 | Percy Jackson & the Olympians: The Lightning Thief | $6,516 | -64% | 12 | -12 | $543 | $790,968 | 9 | 20th Century Fox International | false | false |
| 15 | - | Amelia | $6,350 | - | 7 | - | $907 | $6,350 | 1 | 20th Century Fox International | true | false |
| 16 | 14 | Alvin and the Chipmunks: The Squeakquel | $4,851 | -58% | 10 | -8 | $485 | $1,407,784 | 11 | 20th Century Fox International | false | false |
| 17 | 15 | The Haunting in Connecticut | $4,724 | -55.1% | 4 | - | $1,181 | $198,070 | 13 | Transeuropa | false | false |
| 18 | - | The Burning Plain | $4,294 | - | 3 | - | $1,431 | $4,294 | 1 | N/A | true | false |
| 19 | 16 | The Lovely Bones | $3,113 | -65% | 8 | -3 | $389 | $273,925 | 8 | United International Pictures | false | false |
| 20 | 10 | The Box | $2,583 | -83.7% | 10 | -8 | $258 | $54,673 | 3 | N/A | false | false |
| 21 | 19 | Halloween II | $1,238 | -64.8% | 4 | -3 | $309 | $62,926 | 5 | N/A | false | false |
| 22 | 27 | Everybody's Fine | $801 | -23.6% | 2 | -1 | $400 | $32,530 | 7 | Walt Disney Pictures | false | false |
| 23 | 17 | My Best Friend's Girl | $651 | -89% | 1 | -5 | $651 | $57,331 | 4 | Transeuropa | false | false |
| 24 | 20 | Invictus | $610 | -76.1% | 4 | -2 | $152 | $203,487 | 10 | Warner Bros. | false | false |
| 25 | 18 | The Wolfman | $567 | -88.1% | 4 | -6 | $141 | $762,138 | 9 | United International Pictures | false | false |
| 26 | 24 | The Imaginarium of Doctor Parnassus | $538 | -73.1% | 2 | -1 | $269 | $89,724 | 11 | Sony Pictures Releasing | false | false |
| 27 | 22 | Up in the Air | $523 | -77.3% | 1 | -1 | $523 | $151,441 | 10 | United International Pictures | false | false |
| 28 | 29 | An Education | $508 | +127.8% | 2 | +1 | $254 | $27,571 | 12 | Sony Pictures Releasing | false | false |
| 29 | 23 | Nine | $340 | -83.4% | 2 | -2 | $170 | $51,640 | 8 | Sony Pictures Releasing | false | false |
| 30 | 28 | Welcome to the Sticks | $261 | -55.3% | 1 | - | $261 | $17,260 | 5 | N/A | false | false |
| 31 | 26 | Ponyo | $115 | -92.3% | 3 | -3 | $38 | $36,353 | 7 | Andes Films | false | false |
| 32 | 21 | Valentine's Day | $96 | -96.1% | 1 | -2 | $96 | $320,772 | 9 | Warner Bros. | false | false |
