| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | How to Train Your Dragon | $235,413 | +4.6% | 45 | - | $5,231 | $629,437 | 2 | United International Pictures | false | false |
| 2 | 2 | Alice in Wonderland | $111,966 | -23.6% | 53 | - | $2,112 | $2,146,798 | 5 | Walt Disney Pictures | false | false |
| 3 | - | The Wolfman | $94,264 | - | 30 | - | $3,142 | $94,264 | 1 | United International Pictures | true | false |
| 4 | 3 | Did You Hear About the Morgans? | $28,733 | -26% | 21 | - | $1,368 | $92,743 | 2 | Sony Pictures Releasing | false | false |
| 5 | - | [Rec]² | $27,261 | - | 7 | - | $3,894 | $27,261 | 1 | N/A | true | false |
| 6 | 5 | Edge of Darkness | $23,602 | -33.2% | 14 | - | $1,685 | $82,048 | 2 | - | false | false |
| 7 | 4 | The Book of Eli | $17,511 | -54.6% | 19 | -4 | $921 | $169,736 | 3 | Sony Pictures Releasing | false | false |
| 8 | - | The Hurt Locker | $15,328 | - | 4 | - | $3,832 | $15,328 | 1 | N/A | true | false |
| 9 | - | Invictus | $9,841 | - | 6 | - | $1,640 | $32,259 | 7 | - | false | false |
| 10 | 6 | The Blind Side | $7,147 | -28% | 13 | - | $549 | $114,415 | 4 | - | false | false |
| 11 | - | Over Her Dead Body | $3,429 | - | 4 | - | $857 | $76,868 | 14 | - | false | false |
| 12 | 7 | Armored | $3,123 | -49.7% | 12 | -7 | $260 | $93,586 | 4 | Sony Pictures Releasing | false | false |
| 13 | 10 | Broken Embraces | $1,503 | -45.3% | 6 | - | $250 | $13,800 | 3 | United International Pictures | false | false |
| 14 | 9 | Old Dogs | $1,383 | -56.7% | 14 | -2 | $98 | $632,311 | 8 | Walt Disney Pictures | false | false |
| 15 | 12 | Percy Jackson & the Olympians: The Lightning Thief | $1,240 | -42.6% | 10 | -2 | $124 | $567,555 | 8 | 20th Century Fox International | false | false |
| 16 | 8 | Nine | $1,097 | -76.8% | 6 | - | $182 | $52,625 | 10 | Sony Pictures Releasing | false | false |
| 17 | 17 | Tooth Fairy | $841 | +60.5% | 10 | +3 | $84 | $708,424 | 10 | 20th Century Fox International | false | false |
| 18 | 14 | The Salvation Poem | $236 | -79.8% | 1 | -2 | $236 | $123,314 | 7 | N/A | false | false |
