| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 4 | How to Train Your Dragon | $31,239 | -17% | 8 | - | $3,904 | $79,907 | 2 | United International Pictures | false | false |
| 2 | 3 | My Name Is Khan | $30,602 | -26% | 8 | - | $3,825 | $368,460 | 8 | 20th Century Fox International | false | false |
| 3 | 1 | Alice in Wonderland | $29,668 | -53% | 4 | - | $7,417 | $393,622 | 6 | Walt Disney Pictures | false | false |
| 4 | 2 | The Bounty Hunter | $25,149 | -39.3% | 6 | - | $4,191 | $132,147 | 3 | Sony Pictures Releasing | false | false |
| 5 | 5 | Avatar | $18,841 | -42.6% | 5 | -2 | $3,768 | $2,253,897 | 17 | 20th Century Fox International | false | false |
| 6 | 7 | Remember Me | $15,696 | -30.7% | 5 | - | $3,139 | $44,818 | 2 | - | false | false |
| 7 | 6 | Shutter Island | $14,830 | -50.5% | 10 | - | $1,483 | $205,765 | 5 | United International Pictures | false | false |
| 8 | 8 | From Paris with Love | $11,301 | -42.3% | 8 | - | $1,412 | $143,504 | 5 | N/A | false | false |
| 9 | 9 | Green Zone | $9,490 | -46.3% | 10 | - | $949 | $104,812 | 4 | United International Pictures | false | false |
| 10 | 10 | The Wolfman | $8,046 | -44.3% | 9 | +1 | $894 | $165,415 | 7 | United International Pictures | false | false |
| 11 | 11 | Pandorum | $6,577 | -42.1% | 5 | - | $1,315 | $21,477 | 2 | N/A | false | false |
| 12 | 14 | The Children | $4,056 | -49% | 3 | - | $1,352 | $41,736 | 5 | - | false | false |
| 13 | 16 | When in Rome | $4,012 | -25.9% | 3 | - | $1,337 | $38,000 | 4 | Walt Disney Pictures | false | false |
| 14 | 13 | Valentine's Day | $3,946 | -52.1% | 4 | - | $986 | $258,197 | 9 | Warner Bros. | false | false |
| 15 | 15 | The Book of Eli | $3,938 | -30.5% | 4 | - | $984 | $271,915 | 11 | - | false | false |
| 16 | 12 | The Lovely Bones | $3,649 | -62.2% | 8 | - | $456 | $26,214 | 3 | United International Pictures | false | false |
| 17 | 17 | Stag Night | $1,009 | -53.5% | 1 | - | $1,009 | $35,637 | 7 | N/A | false | false |
| 18 | 19 | It's Complicated | $834 | -16.8% | 4 | -1 | $208 | $122,377 | 10 | United International Pictures | false | false |
| 19 | 18 | Percy Jackson & the Olympians: The Lightning Thief | $726 | -48.9% | 1 | - | $726 | $108,892 | 9 | 20th Century Fox International | false | false |
| 20 | 25 | The Princess and the Frog | $568 | +747.8% | 2 | - | $284 | $79,105 | 15 | Walt Disney Pictures | false | false |
| 21 | 20 | The Tournament | $539 | -7.9% | 1 | - | $539 | $19,088 | 6 | - | false | false |
| 22 | 21 | Alvin and the Chipmunks: The Squeakquel | $423 | -9.2% | 2 | +1 | $211 | $151,013 | 16 | 20th Century Fox International | false | false |
| 23 | 23 | Sherlock Holmes | $219 | -34.2% | 1 | - | $219 | $396,728 | 15 | Warner Bros. | false | false |
| 24 | 24 | Up in the Air | $198 | -27.2% | 2 | - | $99 | $76,132 | 9 | United International Pictures | false | false |
| 25 | 22 | 2012 | $182 | -47.9% | 1 | - | $182 | $1,101,387 | 22 | Sony Pictures Releasing | false | false |
| 26 | - | High Lane | $25 | - | 1 | - | $25 | $22,142 | 11 | N/A | false | false |
