| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | How to Train Your Dragon | $58,717 | +15.4% | 17 | - | $3,453 | $162,977 | 2 | United International Pictures | false | false |
| 2 | - | The Bounty Hunter | $54,268 | - | 12 | - | $4,522 | $54,268 | 1 | Sony Pictures Releasing | true | false |
| 3 | 4 | Alice in Wonderland | $21,542 | +35.9% | 14 | - | $1,538 | $294,632 | 6 | Walt Disney Pictures | false | false |
| 4 | 2 | Shutter Island | $15,087 | -10.9% | 9 | - | $1,676 | $223,798 | 5 | United International Pictures | false | false |
| 5 | 3 | Remember Me | $13,041 | -20.3% | 9 | - | $1,449 | $82,440 | 3 | N/A | false | false |
| 6 | - | Daybreakers | $11,655 | - | 4 | - | $2,913 | $11,655 | 1 | N/A | true | false |
| 7 | 6 | From Paris with Love | $6,751 | -24.8% | 6 | - | $1,125 | $73,102 | 4 | N/A | false | false |
| 8 | 5 | Legion | $6,464 | -58.1% | 8 | +1 | $808 | $31,125 | 2 | Sony Pictures Releasing | false | false |
| 9 | 7 | Leap Year | $4,056 | -39.3% | 5 | -1 | $811 | $57,118 | 4 | United International Pictures | false | false |
| 10 | 8 | The Blind Side | $3,996 | -18.1% | 6 | - | $666 | $91,208 | 6 | Warner Bros. | false | false |
| 11 | 10 | The Young Victoria | $3,659 | +13.9% | 2 | - | $1,829 | $17,575 | 3 | N/A | false | false |
| 12 | 12 | Avatar | $3,416 | +94.3% | 6 | +4 | $569 | $1,646,183 | 17 | 20th Century Fox International | false | false |
| 13 | 11 | The Spy Next Door 2010 Re-release | $3,209 | +61.7% | 4 | -1 | $802 | $74,826 | 7 | N/A | false | false |
| 14 | 9 | Percy Jackson & the Olympians: The Lightning Thief | $3,108 | -12.6% | 6 | - | $518 | $41,723 | 4 | 20th Century Fox International | false | false |
| 15 | 14 | Fantastic Mr. Fox | $437 | -63.2% | 1 | - | $437 | $2,160 | 2 | 20th Century Fox International | false | false |
| 16 | 15 | Crazy Heart | $368 | -10.2% | 1 | - | $368 | $4,864 | 4 | 20th Century Fox International | false | false |
