| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Ghost Writer | $1,382,472 | - | 351 | - | $3,938 | $1,382,472 | 1 | 01 Distribution | true | false |
| 2 | - | Green Zone | $1,355,980 | - | 301 | - | $4,504 | $1,358,187 | 1 | Medusa Distribuzione | true | false |
| 3 | 1 | Life Is a Wonderful Thing | $1,138,321 | -50.2% | 410 | - | $2,776 | $4,871,516 | 2 | Medusa Distribuzione | false | false |
| 4 | 2 | How to Train Your Dragon | $951,173 | -40.3% | 352 | - | $2,702 | $6,307,359 | 3 | Universal Pictures International (UPI) | false | false |
| 5 | - | The Bounty Hunter | $822,345 | - | 256 | - | $3,212 | $822,345 | 1 | Sony Pictures Releasing | true | false |
| 6 | - | Basilicata Coast to Coast | $707,879 | - | 196 | - | $3,611 | $707,879 | 1 | Eagle Pictures | true | false |
| 7 | 3 | Happy Family | $685,492 | -53.7% | 296 | - | $2,315 | $5,153,003 | 3 | 01 Distribution | false | false |
| 8 | 4 | Alice in Wonderland | $502,154 | -58.5% | 217 | - | $2,314 | $40,380,702 | 6 | Walt Disney Pictures | false | false |
| 9 | 5 | I Love You Phillip Morris | $456,993 | -61.3% | 222 | - | $2,058 | $2,296,275 | 2 | Lucky Red | false | false |
| 10 | 6 | Loose Cannons | $370,745 | -50.4% | 140 | - | $2,648 | $10,209,265 | 5 | 01 Distribution | false | false |
| 11 | 7 | Gamer | $234,774 | -65% | 123 | - | $1,908 | $1,273,677 | 2 | N/A | false | false |
| 12 | 9 | It's Complicated | $183,200 | -69.7% | 106 | - | $1,728 | $4,863,246 | 4 | United International Pictures | false | false |
| 13 | 10 | Shutter Island | $152,988 | -59.3% | 71 | - | $2,154 | $9,345,437 | 6 | Medusa Distribuzione | false | false |
| 14 | 11 | Little Nicholas | $148,888 | -56.7% | 159 | - | $936 | $742,091 | 2 | BIM Distribuzione | false | false |
| 15 | 8 | Remember Me | $126,807 | -80.2% | 87 | - | $1,457 | $2,868,937 | 3 | Eagle Pictures | false | false |
| 16 | - | Departures | $100,253 | - | 27 | - | $3,713 | $101,238 | 1 | N/A | true | false |
| 17 | 14 | Avatar | $81,044 | -37.4% | 42 | - | $1,929 | $88,119,807 | 13 | 20th Century Fox International | false | false |
| 18 | 18 | The Concert | $74,514 | -2.3% | 24 | - | $3,104 | $4,418,165 | 10 | BIM Distribuzione | false | false |
| 19 | - | Simon Konianski | $48,426 | - | 25 | - | $1,937 | $48,426 | 1 | Fandango | true | false |
| 20 | 17 | A Prophet | $46,576 | -42.1% | 28 | - | $1,663 | $711,457 | 4 | BIM Distribuzione | false | false |
| 21 | 15 | Percy Jackson & the Olympians: The Lightning Thief | $41,513 | -67.4% | 41 | - | $1,012 | $4,139,909 | 5 | 20th Century Fox International | false | false |
| 22 | - | Leap Year | $36,639 | - | 50 | - | $732 | $36,639 | 1 | N/A | true | false |
| 23 | 12 | Sul mare | $36,262 | -87.8% | 130 | - | $278 | $523,238 | 2 | Warner Bros. | false | false |
| 24 | 16 | Invictus | $33,392 | -67.6% | 19 | - | $1,757 | $8,457,469 | 7 | Warner Bros. | false | false |
| 25 | 20 | Genitori & figli:) - Agitare bene prima dell'uso | $27,113 | -51.6% | 17 | - | $1,594 | $11,409,074 | 7 | Filmauro | false | false |
| 26 | 21 | La valigia sul letto | $25,725 | -42.3% | 9 | -5 | $2,858 | $712,157 | 5 | Medusa Distribuzione | false | false |
| 27 | - | Sunshine Cleaning | $19,064 | - | 27 | - | $706 | $19,064 | 1 | N/A | true | false |
| 28 | 22 | I Am Love | $14,425 | -58.4% | 10 | -12 | $1,442 | $284,612 | 4 | Mikado Film | false | false |
| 29 | 23 | Women Without Men | $11,742 | -43.2% | 7 | -5 | $1,677 | $368,804 | 5 | BIM Distribuzione | false | false |
| 30 | 13 | Daybreakers | $11,302 | -92.3% | 10 | -76 | $1,130 | $770,682 | 3 | Sony Pictures Releasing | false | false |
| 31 | - | Le Bossu | $10,396 | - | 1 | - | $10,396 | $58,518 | - | N/A | - | false |
| 32 | 27 | Incendiary | $9,616 | +16% | 6 | - | $1,602 | $143,379 | 7 | N/A | false | false |
| 33 | 26 | Diamond 13 | $9,262 | +8.3% | 6 | - | $1,543 | $121,631 | 6 | N/A | false | false |
| 34 | - | Kicked in the Head | $5,465 | - | 3 | - | $1,821 | $21,361 | - | N/A | - | false |
| 35 | - | Lourdes | $3,908 | - | 7 | - | $558 | $510,877 | 9 | N/A | false | false |
