| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | How to Train Your Dragon | $1,937,227 | -41.5% | 344 | -17 | $5,631 | $16,117,263 | 4 | Paramount Pictures International | false | false |
| 2 | 3 | Date Night | $1,606,103 | -19.8% | 303 | -1 | $5,300 | $4,478,215 | 2 | 20th Century Fox International | false | false |
| 3 | 2 | Clash of the Titans | $1,571,576 | -47.9% | 345 | -4 | $4,555 | $15,074,138 | 3 | Warner Bros. | false | false |
| 4 | - | The Book of Eli | $1,229,076 | - | 188 | - | $6,537 | $1,229,723 | 1 | Sony Pictures Releasing | true | false |
| 5 | 5 | Kick-Ass | $1,033,157 | -32.8% | 231 | -5 | $4,472 | $3,287,691 | 2 | Universal Pictures International (UPI) | false | false |
| 6 | 4 | Nanny McPhee Returns | $968,009 | -41.5% | 247 | -11 | $3,919 | $6,721,577 | 3 | Universal Pictures International (UPI) | false | false |
| 7 | 6 | The Last Song | $746,292 | -45.4% | 226 | -8 | $3,302 | $5,282,190 | 3 | Walt Disney Pictures | false | false |
| 8 | 7 | Alice in Wonderland | $699,084 | -41.8% | 222 | -154 | $3,149 | $33,387,593 | 7 | Walt Disney Pictures | false | false |
| 9 | - | Beneath Hill 60 | $507,051 | - | 164 | - | $3,091 | $507,462 | 1 | Paramount Pictures International | true | false |
| 10 | 10 | The Girl with the Dragon Tattoo | $300,653 | -23.2% | 60 | +5 | $5,010 | $2,589,637 | 4 | Rialto Distribution | false | false |
| 11 | 8 | She's Out of My League | $279,659 | -49.5% | 171 | -14 | $1,635 | $2,728,403 | 3 | Paramount Pictures International | false | false |
| 12 | 9 | The Spy Next Door 2010 Re-release | $221,257 | -47.9% | 125 | -14 | $1,770 | $1,885,876 | 4 | Roadshow Films | false | false |
| 13 | 11 | The Blind Side | $182,027 | -49.9% | 143 | -24 | $1,272 | $11,894,715 | 8 | Roadshow Films | false | false |
| 14 | 13 | Avatar | $158,464 | -13.9% | 45 | -11 | $3,521 | $104,769,210 | 18 | 20th Century Fox International | false | false |
| 15 | 14 | The Last Station 2010 Re-release | $110,061 | -35.9% | 31 | +5 | $3,550 | $747,044 | 3 | Becker Film Group | false | false |
| 16 | - | Coco Chanel & Igor Stravinsky | $95,795 | - | 29 | - | $3,303 | $163,467 | 1 | Madman Entertainment | true | false |
| 17 | 17 | Micmacs | $76,566 | -36.8% | 32 | +5 | $2,392 | $593,458 | 3 | Hopscotch Films | false | false |
| 18 | 12 | The Bounty Hunter | $66,200 | -70.8% | 63 | -101 | $1,050 | $4,409,434 | 5 | Sony Pictures Releasing | false | false |
| 19 | 18 | Welcome | $63,947 | -22.5% | 20 | +1 | $3,197 | $383,811 | 3 | Palace Films | false | false |
| 20 | 15 | The Hurt Locker | $61,869 | -63% | 57 | -14 | $1,085 | $5,021,453 | 9 | Roadshow Films | false | false |
| 21 | - | The Eclipse | $25,469 | - | 9 | - | $2,829 | $25,469 | 1 | Jump Street Films | true | false |
| 22 | - | Paathshaala | $20,588 | - | 11 | - | $1,871 | $20,588 | 1 | Eros Worldwide | true | false |
