| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Clash of the Titans | $714,143 | - | 103 | - | $6,933 | $726,320 | 1 | Warner Bros. | true | false |
| 2 | 1 | How to Train Your Dragon | $125,535 | -43.8% | 52 | -15 | $2,414 | $1,154,047 | 4 | United International Pictures | false | false |
| 3 | 2 | Shutter Island | $120,778 | -34.7% | 34 | -1 | $3,552 | $367,534 | 2 | United International Pictures | false | false |
| 4 | 3 | Legion | $29,579 | -55.4% | 26 | - | $1,137 | $418,195 | 4 | Sony Pictures Releasing | false | false |
| 5 | - | The Young Victoria | $21,094 | - | 8 | - | $2,636 | $21,094 | 1 | N/A | true | false |
| 6 | 4 | Edge of Darkness | $21,000 | -45.1% | 28 | - | $750 | $164,586 | 3 | Warner Bros. | false | false |
| 7 | - | The Secret in Their Eyes | $11,437 | - | 3 | - | $3,812 | $423,113 | 15 | N/A | false | false |
| 8 | 7 | 500 Days of Summer | $6,451 | -45.1% | 5 | -2 | $1,290 | $125,421 | 6 | 20th Century Fox International | false | false |
| 9 | 11 | Let the Right One In | $6,227 | -25.1% | 5 | - | $1,245 | $45,739 | 4 | N/A | false | false |
| 10 | 17 | The Haunting in Connecticut | $5,604 | +18.6% | 3 | -1 | $1,868 | $204,603 | 14 | Transeuropa | false | false |
| 11 | 6 | My Life in Ruins | $5,445 | -63.2% | 11 | -4 | $495 | $23,690 | 2 | N/A | false | false |
| 12 | 10 | The Blind Side | $4,845 | -45.2% | 4 | -2 | $1,211 | $93,608 | 5 | Warner Bros. | false | false |
| 13 | 9 | Daybreakers | $3,763 | -65.7% | 11 | -4 | $342 | $55,163 | 3 | N/A | false | false |
| 14 | 8 | The Hurt Locker | $3,371 | -70.3% | 6 | -9 | $561 | $347,396 | 9 | N/A | false | false |
| 15 | 14 | Percy Jackson & the Olympians: The Lightning Thief | $3,311 | -49.2% | 8 | -4 | $413 | $795,184 | 10 | 20th Century Fox International | false | false |
| 16 | 12 | The Men Who Stare at Goats | $3,309 | -58.9% | 4 | -4 | $827 | $36,296 | 3 | Sony Pictures Releasing | false | false |
| 17 | 5 | Avatar | $3,143 | -87.3% | 14 | -18 | $224 | $10,398,155 | 18 | 20th Century Fox International | false | false |
| 18 | 13 | [Rec]² | $2,384 | -63.5% | 8 | -5 | $298 | $94,246 | 5 | N/A | false | false |
| 19 | 16 | Alvin and the Chipmunks: The Squeakquel | $1,985 | -59.1% | 5 | -5 | $397 | $1,410,206 | 12 | 20th Century Fox International | false | false |
| 20 | 19 | The Lovely Bones | $1,542 | -50.5% | 2 | -6 | $771 | $276,533 | 9 | United International Pictures | false | false |
| 21 | 15 | Amelia | $1,162 | -81.7% | 5 | -2 | $232 | $8,871 | 2 | 20th Century Fox International | false | false |
| 22 | 18 | The Burning Plain | $970 | -77.4% | 2 | -1 | $485 | $6,739 | 2 | N/A | false | false |
| 23 | 23 | My Best Friend's Girl | $668 | +2.6% | 1 | - | $668 | $59,152 | 5 | Transeuropa | false | false |
| 24 | 21 | Halloween II | $343 | -72.3% | 2 | -2 | $171 | $63,614 | 6 | N/A | false | false |
| 25 | 27 | Up in the Air | $275 | -47.4% | 1 | - | $275 | $151,820 | 11 | United International Pictures | false | false |
| 26 | 30 | Welcome to the Sticks | $266 | +1.9% | 1 | - | $266 | $17,543 | 6 | N/A | false | false |
| 27 | 20 | The Box | $214 | -91.7% | 3 | -7 | $71 | $55,749 | 4 | N/A | false | false |
| 28 | 32 | Valentine's Day | $157 | +63.5% | 1 | - | $157 | $320,998 | 10 | Warner Bros. | false | false |
| 29 | 25 | The Wolfman | $120 | -78.8% | 1 | -3 | $120 | $762,258 | 10 | United International Pictures | false | false |
