| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Clash of the Titans | $133,760 | - | 9 | - | $14,862 | $133,760 | 1 | Warner Bros. | true | false |
| 2 | 2 | My Name Is Khan | $28,036 | -8.4% | 8 | - | $3,504 | $403,113 | 9 | 20th Century Fox International | false | false |
| 3 | 3 | Alice in Wonderland | $23,082 | -22.2% | 4 | - | $5,770 | $421,760 | 7 | Walt Disney Pictures | false | false |
| 4 | 4 | The Bounty Hunter | $20,976 | -16.6% | 6 | - | $3,496 | $157,660 | 4 | Sony Pictures Releasing | false | false |
| 5 | 1 | How to Train Your Dragon | $19,106 | -38.8% | 8 | - | $2,388 | $102,397 | 3 | United International Pictures | false | false |
| 6 | 6 | Remember Me | $14,526 | -7.5% | 5 | - | $2,905 | $62,265 | 3 | - | false | false |
| 7 | 7 | Shutter Island | $13,440 | -9.4% | 10 | - | $1,344 | $222,407 | 6 | United International Pictures | false | false |
| 8 | 5 | Avatar | $8,630 | -54.2% | 2 | -3 | $4,315 | $2,266,358 | 18 | 20th Century Fox International | false | false |
| 9 | 8 | From Paris with Love | $8,261 | -26.9% | 8 | - | $1,032 | $154,220 | 6 | N/A | false | false |
| 10 | 9 | Green Zone | $6,916 | -27.1% | 1 | -9 | $6,916 | $113,582 | 5 | United International Pictures | false | false |
| 11 | 10 | The Wolfman | $5,159 | -35.9% | 9 | - | $573 | $172,757 | 8 | United International Pictures | false | false |
| 12 | 13 | When in Rome | $4,593 | +14.5% | 3 | - | $1,531 | $43,638 | 5 | Walt Disney Pictures | false | false |
| 13 | 11 | Pandorum | $3,372 | -48.7% | 5 | - | $674 | $26,162 | 3 | N/A | false | false |
| 14 | 15 | The Book of Eli | $3,081 | -21.8% | 4 | - | $770 | $275,715 | 12 | - | false | false |
| 15 | 14 | Valentine's Day | $2,395 | -39.3% | 3 | -1 | $798 | $261,470 | 10 | Warner Bros. | false | false |
| 16 | - | Astro Boy | $2,073 | - | 3 | - | $691 | $2,073 | 1 | - | true | false |
| 17 | 12 | The Children | $1,519 | -62.5% | 2 | -1 | $759 | $44,088 | 6 | - | false | false |
| 18 | 16 | The Lovely Bones | $1,181 | -67.6% | 8 | - | $147 | $27,846 | 4 | United International Pictures | false | false |
| 19 | 18 | It's Complicated | $1,008 | +20.9% | 3 | -1 | $336 | $123,614 | 11 | United International Pictures | false | false |
| 20 | 17 | Stag Night | $579 | -42.6% | 1 | - | $579 | $36,472 | 8 | N/A | false | false |
| 21 | 22 | Alvin and the Chipmunks: The Squeakquel | $457 | +8% | 1 | -1 | $457 | $151,470 | 17 | 20th Century Fox International | false | false |
| 22 | 19 | Percy Jackson & the Olympians: The Lightning Thief | $371 | -48.9% | 1 | - | $371 | $109,326 | 10 | 20th Century Fox International | false | false |
| 23 | 23 | Sherlock Holmes | $329 | +50.2% | 1 | - | $329 | $397,088 | 16 | Warner Bros. | false | false |
| 24 | 20 | The Princess and the Frog | $84 | -85.2% | 1 | -1 | $84 | $79,189 | 16 | Walt Disney Pictures | false | false |
| 25 | 26 | High Lane | $57 | +128% | 1 | - | $57 | $22,200 | 12 | N/A | false | false |
| 26 | 24 | Up in the Air | $39 | -80.3% | 1 | -1 | $39 | $76,195 | 10 | United International Pictures | false | false |
