| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Clash of the Titans | $67,224 | - | 8 | - | $8,403 | $67,762 | 1 | Warner Bros. | true | false |
| 2 | 1 | How to Train Your Dragon | $29,347 | -9.2% | 9 | - | $3,260 | $106,048 | 2 | United International Pictures | false | false |
| 3 | - | Date Night | $19,925 | - | 4 | - | $4,981 | $20,515 | 1 | 20th Century Fox International | true | false |
| 4 | 2 | Hot Tub Time Machine | $14,897 | -24.3% | 4 | - | $3,724 | $74,688 | 2 | N/A | false | false |
| 5 | 3 | I Love You Phillip Morris | $8,977 | -28% | 3 | - | $2,992 | $46,375 | 2 | N/A | false | false |
| 6 | 4 | King's Road | $5,868 | -17.9% | 2 | -1 | $2,934 | $49,999 | 3 | N/A | false | false |
| 7 | 6 | Dear John | $3,667 | -3.1% | 3 | - | $1,222 | $16,322 | 2 | N/A | false | false |
| 8 | 5 | The Bounty Hunter | $2,933 | -26.9% | 2 | -1 | $1,466 | $79,895 | 4 | Sony Pictures Releasing | false | false |
| 9 | 7 | Nanny McPhee Returns | $2,926 | -21.3% | 4 | - | $731 | $21,421 | 3 | United International Pictures | false | false |
| 10 | 10 | The Girl Who Kicked the Hornet's Nest | $2,213 | +38.7% | 1 | - | $2,213 | $178,159 | 8 | N/A | false | false |
| 11 | 8 | Alice in Wonderland | $1,790 | -49.6% | 1 | -2 | $1,790 | $212,418 | 6 | Walt Disney Pictures | false | false |
| 12 | 9 | When in Rome | $1,753 | -18.7% | 2 | -1 | $876 | $19,898 | 3 | Walt Disney Pictures | false | false |
| 13 | 11 | The Men Who Stare at Goats | $1,266 | -15.3% | 1 | -1 | $1,266 | $15,186 | 3 | N/A | false | false |
| 14 | 12 | The Blind Side | $741 | -47.9% | 1 | - | $741 | $44,843 | 5 | Warner Bros. | false | false |
| 15 | 15 | The Lovely Bones | $633 | -28.5% | 2 | - | $316 | $12,700 | 4 | United International Pictures | false | false |
| 16 | 14 | The Good Heart | $573 | -45.7% | 1 | -1 | $573 | $29,560 | 6 | N/A | false | false |
| 17 | 13 | Green Zone | $550 | -60.4% | 1 | -1 | $550 | $64,727 | 5 | United International Pictures | false | false |
| 18 | 17 | Shutter Island | $461 | -43.2% | 1 | - | $461 | $120,750 | 7 | United International Pictures | false | false |
| 19 | 20 | Cloudy with a Chance of Meatballs | $438 | -18.3% | 2 | - | $219 | $92,303 | 11 | Sony Pictures Releasing | false | false |
| 20 | 16 | Daybreakers | $79 | -90.3% | 1 | - | $79 | $13,394 | 4 | N/A | false | false |
