| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 2 | How to Train Your Dragon | $252,107 | -29.8% | 95 | - | $2,653 | $1,680,835 | 3 | United International Pictures | false | false |
| 2 | - | Date Night | $205,308 | - | 60 | - | $3,421 | $205,308 | 1 | 20th Century Fox International | true | false |
| 3 | 1 | The Bounty Hunter | $197,508 | -55.4% | 57 | - | $3,465 | $916,128 | 2 | Sony Pictures Releasing | false | false |
| 4 | 4 | Tooth Fairy | $121,262 | -26.6% | 64 | - | $1,894 | $1,343,559 | 4 | 20th Century Fox International | false | false |
| 5 | 3 | Alice in Wonderland | $116,001 | -35% | 78 | -2 | $1,487 | $3,098,200 | 6 | Walt Disney Pictures | false | false |
| 6 | 6 | Nanny McPhee Returns | $93,814 | -17.3% | 42 | - | $2,233 | $337,311 | 2 | United International Pictures | false | false |
| 7 | 5 | The Blind Side | $80,511 | -32.5% | 52 | -1 | $1,548 | $875,463 | 4 | Warner Bros. | false | false |
| 8 | 7 | It's Complicated | $42,710 | -45.9% | 53 | - | $805 | $1,448,984 | 7 | United International Pictures | false | false |
| 9 | 9 | The Hurt Locker | $35,805 | -36.7% | 20 | -1 | $1,790 | $246,329 | 3 | NuMetro Distribution | false | false |
| 10 | 8 | Shutter Island | $31,933 | -49.9% | 30 | -5 | $1,064 | $641,486 | 5 | United International Pictures | false | false |
| 11 | 11 | The Book of Eli | $13,126 | -57.4% | 21 | -7 | $625 | $775,736 | 7 | Sony Pictures Releasing | false | false |
| 12 | - | Outrageous | $12,995 | - | 22 | - | $590 | $12,995 | 1 | N/A | true | false |
| 13 | 10 | Armored | $12,530 | -67.5% | 18 | -13 | $696 | $168,261 | 3 | Sony Pictures Releasing | false | false |
| 14 | - | The Descent: Part 2 | $11,714 | - | 12 | - | $976 | $11,714 | 1 | Ster-Kinekor Pictures | true | false |
| 15 | 15 | The Last Station 2010 Re-release | $11,555 | -32.3% | 7 | -3 | $1,650 | $71,016 | 3 | Ster-Kinekor Pictures | false | false |
| 16 | 12 | Avatar | $11,245 | -60.9% | 4 | -4 | $2,811 | $7,780,468 | 17 | 20th Century Fox International | false | false |
| 17 | - | Away We Go | $10,991 | - | 10 | - | $1,099 | $10,991 | 1 | NuMetro Distribution | true | false |
| 18 | 16 | The Spy Next Door 2010 Re-release | $7,382 | -51% | 11 | -6 | $671 | $657,394 | 10 | N/A | false | false |
| 19 | 14 | Fast & Frantic | $7,040 | -62.9% | 17 | -8 | $414 | $39,523 | 2 | NuMetro Distribution | false | false |
| 20 | 13 | Valentine's Day | $6,976 | -67.6% | 13 | -18 | $536 | $1,583,752 | 9 | NuMetro Distribution | false | false |
| 21 | 17 | Nine | $6,924 | -43.6% | 6 | -2 | $1,154 | $186,064 | 5 | Sony Pictures Releasing | false | false |
| 22 | 21 | An Education | $3,845 | -11.1% | 6 | +1 | $640 | $188,373 | 11 | United International Pictures | false | false |
| 23 | - | Quick Gun Murugun: Misadventures of an Indian Cowboy | $2,070 | - | 5 | - | $414 | $2,070 | 1 | N/A | true | false |
| 24 | 22 | Up in the Air | $1,295 | -66.8% | 6 | - | $215 | $454,347 | 11 | United International Pictures | false | false |
