| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Hot Tub Time Machine | $1,182,864 | - | 204 | - | $5,798 | $1,182,864 | 1 | 20th Century Fox International | true | false |
| 2 | 2 | Date Night | $1,174,362 | -26.9% | 282 | -21 | $4,164 | $6,174,054 | 3 | 20th Century Fox International | false | false |
| 3 | 3 | Clash of the Titans | $965,384 | -38.6% | 306 | -39 | $3,154 | $16,575,994 | 4 | Warner Bros. | false | false |
| 4 | 1 | How to Train Your Dragon | $854,634 | -55.9% | 310 | -34 | $2,756 | $17,500,728 | 5 | Paramount Pictures International | false | false |
| 5 | 4 | The Book of Eli | $772,551 | -37.1% | 190 | +2 | $4,066 | $2,439,940 | 2 | Sony Pictures Releasing | false | false |
| 6 | - | When in Rome | $743,069 | - | 211 | - | $3,521 | $743,069 | 1 | Walt Disney Pictures | true | false |
| 7 | 5 | Kick-Ass | $704,613 | -31.8% | 206 | -25 | $3,420 | $4,386,287 | 3 | Universal Pictures International (UPI) | false | false |
| 8 | 9 | Beneath Hill 60 | $580,127 | +14.4% | 164 | - | $3,537 | $1,340,243 | 2 | Paramount Pictures International | false | false |
| 9 | 7 | The Last Song | $365,285 | -51.1% | 205 | -21 | $1,781 | $5,865,399 | 4 | Walt Disney Pictures | false | false |
| 10 | 8 | Alice in Wonderland | $362,569 | -48.1% | 154 | -68 | $2,354 | $34,189,355 | 8 | Walt Disney Pictures | false | false |
| 11 | 10 | The Girl with the Dragon Tattoo | $357,361 | +18.9% | 69 | +9 | $5,179 | $3,068,674 | 5 | Rialto Distribution | false | false |
| 12 | 6 | Nanny McPhee Returns | $324,447 | -66.5% | 236 | -11 | $1,374 | $7,286,458 | 4 | Universal Pictures International (UPI) | false | false |
| 13 | 14 | Avatar | $280,722 | +77.2% | 59 | +14 | $4,758 | $105,493,615 | 19 | 20th Century Fox International | false | false |
| 14 | 13 | The Blind Side | $140,981 | -22.5% | 109 | -34 | $1,293 | $12,147,211 | 9 | Roadshow Films | false | false |
| 15 | 15 | The Last Station 2010 Re-release | $108,152 | -1.7% | 41 | +10 | $2,637 | $905,475 | 4 | Becker Film Group | false | false |
| 16 | 11 | She's Out of My League | $100,675 | -64% | 104 | -67 | $968 | $2,937,685 | 4 | Paramount Pictures International | false | false |
| 17 | 20 | The Hurt Locker | $80,974 | +30.9% | 63 | +6 | $1,285 | $5,142,645 | 10 | Roadshow Films | false | false |
| 18 | 16 | Coco Chanel & Igor Stravinsky | $75,564 | -21.1% | 30 | +1 | $2,518 | $278,556 | 2 | Madman Entertainment | false | false |
| 19 | 17 | Micmacs | $72,884 | -4.8% | 27 | -5 | $2,699 | $694,292 | 4 | Hopscotch Films | false | false |
| 20 | 19 | Welcome | $71,304 | +11.5% | 23 | +3 | $3,100 | $479,723 | 4 | Palace Films | false | false |
| 21 | - | The Concert | $45,506 | - | 25 | - | $1,820 | $45,506 | - | Hopscotch Films | - | false |
| 22 | - | Accidents Happen | $36,857 | - | 12 | - | $3,071 | $36,857 | 1 | Hopscotch Films | true | false |
| 23 | - | The Burning Plain | $11,783 | - | 4 | - | $2,945 | $11,783 | 1 | Icon Film Distribution | true | false |
| 24 | - | Bunny and the Bull | $8,452 | - | 1 | - | $8,452 | $8,452 | 1 | Madman Entertainment | true | false |
