| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | How to Train Your Dragon | $121,317 | -18.1% | 15 | -31 | $8,087 | $1,009,547 | 4 | United International Pictures | false | false |
| 2 | - | Shutter Island | $45,858 | - | 16 | - | $2,866 | $45,858 | 1 | United International Pictures | true | false |
| 3 | 4 | Alice in Wonderland | $44,082 | -21.1% | 42 | +13 | $1,049 | $2,290,953 | 7 | Walt Disney Pictures | false | false |
| 4 | 2 | Date Night | $42,777 | -33.3% | 25 | - | $1,711 | $141,699 | 2 | 20th Century Fox International | false | false |
| 5 | - | Dear John | $36,174 | - | 23 | - | $1,572 | $36,174 | 1 | Sony Pictures Releasing | true | false |
| 6 | 3 | The Wolfman | $33,673 | -46.1% | 30 | - | $1,122 | $281,536 | 3 | United International Pictures | false | false |
| 7 | - | When in Rome | $30,077 | - | 14 | - | $2,148 | $30,077 | 1 | Walt Disney Pictures | true | false |
| 8 | 5 | It's Complicated | $18,395 | -21.5% | 15 | - | $1,226 | $56,188 | 2 | United International Pictures | false | false |
| 9 | 6 | [Rec]² | $7,356 | -49.8% | 4 | -3 | $1,839 | $78,523 | 3 | N/A | false | false |
| 10 | - | Everybody's Fine | $6,832 | - | 8 | - | $854 | $81,241 | 12 | Walt Disney Pictures | false | false |
| 11 | 7 | The Hurt Locker | $4,447 | -43.1% | 4 | - | $1,111 | $38,862 | 3 | N/A | false | false |
| 12 | 9 | Did You Hear About the Morgans? | $4,015 | -42% | 13 | -5 | $308 | $119,037 | 4 | Sony Pictures Releasing | false | false |
| 13 | 10 | An Education | $1,285 | -77.4% | 6 | - | $214 | $9,332 | 2 | Sony Pictures Releasing | false | false |
| 14 | 17 | Percy Jackson & the Olympians: The Lightning Thief | $1,078 | +27.7% | 12 | +7 | $89 | $570,247 | 10 | 20th Century Fox International | false | false |
| 15 | 15 | Old Dogs | $922 | -10.3% | 5 | -9 | $184 | $634,561 | 10 | Walt Disney Pictures | false | false |
| 16 | 18 | Tooth Fairy | $485 | -18.5% | 8 | - | $60 | $709,676 | 12 | 20th Century Fox International | false | false |
