| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Date Night | $170,955 | - | 25 | - | $6,838 | $186,953 | 1 | 20th Century Fox International | true | false |
| 2 | 1 | The Book of Eli | $139,394 | -53.2% | 20 | - | $6,969 | $511,954 | 2 | Sony Pictures Releasing | false | false |
| 3 | 2 | Clash of the Titans | $117,251 | -54.1% | 62 | -21 | $1,891 | $3,062,278 | 4 | Warner Bros. | false | false |
| 4 | - | Cop Out | $98,690 | - | 26 | - | $3,795 | $137,101 | 1 | Warner Bros. | true | false |
| 5 | - | Toy Story 2009 Re-release | $65,049 | - | 18 | - | $3,613 | $65,049 | 1 | Walt Disney Pictures | true | false |
| 6 | 11 | Shutter Island | $28,701 | +624.2% | 6 | +5 | $4,783 | $624,752 | 8 | United International Pictures | false | false |
| 7 | 4 | When in Rome | $22,533 | -62.8% | 14 | -11 | $1,609 | $297,651 | 3 | Walt Disney Pictures | false | false |
| 8 | 3 | How to Train Your Dragon | $20,647 | -68.7% | 9 | -20 | $2,294 | $1,467,532 | 5 | United International Pictures | false | false |
| 9 | 5 | Green Zone | $19,532 | -41.6% | 9 | -15 | $2,170 | $887,205 | 7 | United International Pictures | false | false |
| 10 | 9 | Alice in Wonderland | $18,896 | +236.8% | 8 | +6 | $2,362 | $2,039,745 | 8 | Walt Disney Pictures | false | false |
| 11 | 12 | The Wolfman | $6,008 | +266.1% | 1 | -1 | $6,008 | $1,090,434 | 10 | United International Pictures | false | false |
| 12 | - | Old Dogs | $5,806 | - | 3 | - | $1,935 | $437,868 | 21 | Walt Disney Pictures | false | false |
| 13 | 10 | Percy Jackson & the Olympians: The Lightning Thief | $4,511 | -14.7% | 4 | +2 | $1,127 | $1,541,717 | 11 | 20th Century Fox International | false | false |
| 14 | 7 | The Lovely Bones | $836 | -92.8% | 4 | -9 | $209 | $65,710 | 3 | United International Pictures | false | false |
| 15 | 13 | Avatar | $467 | -25.2% | 1 | - | $467 | $6,052,917 | 19 | 20th Century Fox International | false | false |
