| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Clash of the Titans | $452,434 | - | 83 | - | $5,451 | $452,434 | 1 | Warner Bros. | true | false |
| 2 | 3 | The Bounty Hunter | $112,176 | -43.2% | 57 | - | $1,968 | $1,073,693 | 3 | Sony Pictures Releasing | false | false |
| 3 | 2 | Date Night | $112,075 | -45.4% | 59 | -1 | $1,899 | $376,729 | 2 | 20th Century Fox International | false | false |
| 4 | 1 | How to Train Your Dragon | $106,984 | -57.6% | 73 | -22 | $1,465 | $1,800,062 | 4 | United International Pictures | false | false |
| 5 | - | Leap Year | $72,350 | - | 40 | - | $1,808 | $72,350 | 1 | United International Pictures | true | false |
| 6 | 4 | Tooth Fairy | $54,887 | -54.7% | 62 | -2 | $885 | $1,391,120 | 5 | 20th Century Fox International | false | false |
| 7 | 6 | Nanny McPhee Returns | $49,887 | -46.8% | 40 | -2 | $1,247 | $394,110 | 3 | United International Pictures | false | false |
| 8 | 7 | The Blind Side | $47,813 | -40.6% | 48 | -4 | $996 | $936,473 | 5 | Warner Bros. | false | false |
| 9 | - | Hachi: A Dog's Tale | $47,113 | - | 24 | - | $1,963 | $47,113 | 1 | Ster-Kinekor Pictures | true | false |
| 10 | 5 | Alice in Wonderland | $41,039 | -64.6% | 49 | -29 | $837 | $3,112,537 | 7 | Walt Disney Pictures | false | false |
| 11 | 9 | The Hurt Locker | $20,347 | -43.2% | 19 | -1 | $1,070 | $277,869 | 4 | NuMetro Distribution | false | false |
| 12 | 8 | It's Complicated | $19,783 | -53.7% | 28 | -25 | $706 | $1,462,365 | 8 | United International Pictures | false | false |
| 13 | 10 | Shutter Island | $13,298 | -58.4% | 22 | -8 | $604 | $661,225 | 6 | United International Pictures | false | false |
| 14 | 15 | The Last Station 2010 Re-release | $9,843 | -14.8% | 9 | +2 | $1,093 | $85,342 | 4 | Ster-Kinekor Pictures | false | false |
| 15 | 17 | Away We Go | $7,132 | -35.1% | 10 | - | $713 | $22,429 | 2 | NuMetro Distribution | false | false |
| 16 | 12 | Outrageous | $5,802 | -55.4% | 11 | -11 | $527 | $23,255 | 2 | N/A | false | false |
| 17 | 21 | Nine | $5,658 | -18.3% | 6 | - | $943 | $191,292 | 6 | Sony Pictures Releasing | false | false |
| 18 | 14 | The Descent: Part 2 | $5,509 | -53% | 12 | - | $459 | $22,056 | 2 | Ster-Kinekor Pictures | false | false |
| 19 | 18 | The Spy Next Door 2010 Re-release | $5,125 | -30.6% | 9 | -2 | $569 | $652,167 | 11 | N/A | false | false |
| 20 | 11 | The Book of Eli | $4,686 | -64.3% | 13 | -8 | $360 | $772,044 | 8 | Sony Pictures Releasing | false | false |
| 21 | - | Precious | $3,590 | - | 8 | - | $448 | $157,428 | 7 | N/A | false | false |
| 22 | 22 | An Education | $3,153 | -18% | 5 | -1 | $630 | $189,780 | 12 | United International Pictures | false | false |
| 23 | 24 | Up in the Air | $1,261 | -2.6% | 2 | -4 | $630 | $447,997 | 12 | United International Pictures | false | false |
