| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Iron Man 2 | $8,792,360 | - | 473 | - | $18,588 | $8,792,360 | 1 | Paramount Pictures International | true | false |
| 2 | 1 | Hot Tub Time Machine | $599,721 | -49.3% | 203 | -1 | $2,954 | $2,378,576 | 2 | 20th Century Fox International | false | false |
| 3 | 2 | Date Night | $579,031 | -50.7% | 250 | -32 | $2,316 | $7,257,732 | 4 | 20th Century Fox International | false | false |
| 4 | 6 | When in Rome | $474,192 | -36.2% | 200 | -11 | $2,370 | $1,619,852 | 2 | Walt Disney Pictures | false | false |
| 5 | 8 | Beneath Hill 60 | $332,769 | -42.6% | 163 | -1 | $2,041 | $2,046,767 | 3 | Paramount Pictures International | false | false |
| 6 | 4 | How to Train Your Dragon | $331,779 | -61.2% | 225 | -85 | $1,474 | $18,237,458 | 6 | Paramount Pictures International | false | false |
| 7 | 3 | Clash of the Titans | $320,255 | -66.8% | 222 | -84 | $1,442 | $17,343,230 | 5 | Warner Bros. | false | false |
| 8 | 7 | Kick-Ass | $297,888 | -57.7% | 182 | -24 | $1,636 | $5,040,729 | 4 | Universal Pictures International (UPI) | false | false |
| 9 | 5 | The Book of Eli | $294,890 | -61.8% | 172 | -18 | $1,714 | $3,118,035 | 3 | Sony Pictures Releasing | false | false |
| 10 | 11 | The Girl with the Dragon Tattoo | $255,644 | -28.5% | 78 | +9 | $3,277 | $3,503,231 | 6 | Rialto Distribution | false | false |
| 11 | 13 | Avatar | $155,814 | -44.5% | 57 | -2 | $2,733 | $105,469,549 | 20 | 20th Century Fox International | false | false |
| 12 | 9 | The Last Song | $152,490 | -58.3% | 144 | -61 | $1,058 | $6,207,497 | 5 | Walt Disney Pictures | false | false |
| 13 | 10 | Alice in Wonderland | $143,147 | -60.5% | 69 | -85 | $2,074 | $34,440,070 | 9 | Walt Disney Pictures | false | false |
| 14 | - | Housefull | $138,614 | - | 18 | - | $7,700 | $138,614 | 1 | Eros Worldwide | true | false |
| 15 | - | The Concert | $123,377 | - | 28 | - | $4,406 | $191,531 | 1 | Hopscotch Films | true | false |
| 16 | 12 | Nanny McPhee Returns | $113,277 | -65.1% | 179 | -57 | $632 | $7,551,455 | 5 | Universal Pictures International (UPI) | false | false |
| 17 | 15 | The Last Station 2010 Re-release | $76,675 | -29.1% | 50 | +9 | $1,533 | $1,040,696 | 5 | Becker Film Group | false | false |
| 18 | 14 | The Blind Side | $58,430 | -58.6% | 76 | -33 | $768 | $12,273,902 | 10 | Roadshow Films | false | false |
| 19 | 17 | The Hurt Locker | $57,650 | -28.8% | 62 | -1 | $929 | $5,226,567 | 11 | Roadshow Films | false | false |
| 20 | 20 | Welcome | $45,996 | -35.5% | 19 | -4 | $2,420 | $558,706 | 5 | Palace Films | false | false |
| 21 | 19 | Micmacs | $41,299 | -43.3% | 23 | -4 | $1,795 | $820,923 | 5 | Hopscotch Films | false | false |
