| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Iron Man 2 | $554,345 | - | 96 | - | $5,774 | $557,126 | 1 | United International Pictures | true | false |
| 2 | 1 | Clash of the Titans | $244,970 | -31.5% | 77 | -15 | $3,181 | $1,595,043 | 3 | Warner Bros. | false | false |
| 3 | 2 | How to Train Your Dragon | $106,644 | -1.7% | 59 | +7 | $1,807 | $1,413,604 | 6 | United International Pictures | false | false |
| 4 | 3 | Shutter Island | $81,635 | -9.1% | 31 | -1 | $2,633 | $603,977 | 4 | United International Pictures | false | false |
| 5 | 4 | The Bounty Hunter | $30,090 | -38.1% | 22 | - | $1,367 | $89,932 | 2 | Sony Pictures Releasing | false | false |
| 6 | 5 | Remember Me | $29,771 | -9.8% | 17 | +1 | $1,751 | $72,458 | 2 | N/A | false | false |
| 7 | 6 | The Girl with the Dragon Tattoo | $21,204 | -27.5% | 11 | -1 | $1,927 | $59,086 | 2 | Andes Films | false | false |
| 8 | 7 | The Young Victoria | $14,399 | -17.1% | 5 | -3 | $2,879 | $64,687 | 3 | N/A | false | false |
| 9 | - | Spread | $11,938 | - | 9 | - | $1,326 | $11,938 | 1 | N/A | true | false |
| 10 | 8 | Law Abiding Citizen | $5,030 | -70.5% | 10 | -9 | $503 | $27,973 | 2 | Transeuropa | false | false |
| 11 | 9 | The Secret in Their Eyes | $4,787 | -52.1% | 2 | -1 | $2,393 | $446,321 | 17 | N/A | false | false |
| 12 | 10 | Legion | $4,060 | -58.9% | 7 | -12 | $580 | $443,197 | 6 | Sony Pictures Releasing | false | false |
| 13 | 14 | Avatar | $3,435 | +22.8% | 13 | - | $264 | $10,488,974 | 20 | 20th Century Fox International | false | false |
| 14 | 11 | Edge of Darkness | $2,384 | -72.3% | 4 | -9 | $596 | $184,033 | 5 | Warner Bros. | false | false |
| 15 | 12 | The Haunting in Connecticut | $1,701 | -47.8% | 3 | -3 | $567 | $214,186 | 16 | Transeuropa | false | false |
| 16 | 13 | Let the Right One In | $1,559 | -50% | 3 | -2 | $519 | $54,052 | 6 | N/A | false | false |
| 17 | 16 | The Men Who Stare at Goats | $913 | -65% | 3 | -5 | $304 | $41,711 | 5 | Sony Pictures Releasing | false | false |
| 18 | 15 | 500 Days of Summer | $682 | -75.2% | 4 | - | $170 | $132,235 | 8 | 20th Century Fox International | false | false |
| 19 | 17 | Alvin and the Chipmunks: The Squeakquel | $632 | -50.4% | 1 | -2 | $632 | $1,424,935 | 14 | 20th Century Fox International | false | false |
| 20 | 24 | The Blind Side | $305 | +5.2% | 1 | - | $305 | $96,354 | 7 | Warner Bros. | false | false |
| 21 | 26 | The Burning Plain | $244 | +216.9% | 1 | - | $244 | $8,106 | 4 | N/A | false | false |
| 22 | 22 | My Life in Ruins | $221 | -50.1% | 2 | -2 | $110 | $25,982 | 4 | N/A | false | false |
| 23 | 23 | Daybreakers | $113 | -70.2% | 1 | -3 | $113 | $57,831 | 5 | N/A | false | false |
| 24 | 18 | Percy Jackson & the Olympians: The Lightning Thief | $19 | -98% | 1 | -2 | $19 | $803,087 | 12 | 20th Century Fox International | false | false |
