| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Clash of the Titans | $397,301 | - | 43 | - | $9,239 | $397,301 | 1 | - | true | false |
| 2 | 2 | Shutter Island | $32,654 | -28.8% | 15 | -1 | $2,176 | $102,670 | 2 | United International Pictures | false | false |
| 3 | 5 | Dear John | $29,792 | -17.6% | 25 | +2 | $1,191 | $82,684 | 2 | Sony Pictures Releasing | false | false |
| 4 | - | 9 | $28,993 | - | 11 | - | $2,635 | $28,993 | 1 | N/A | true | false |
| 5 | 1 | How to Train Your Dragon | $24,015 | -80.2% | 25 | +10 | $960 | $1,062,236 | 5 | United International Pictures | false | false |
| 6 | 7 | When in Rome | $21,747 | -27.7% | 14 | - | $1,553 | $67,586 | 2 | Walt Disney Pictures | false | false |
| 7 | 4 | Date Night | $19,184 | -55.2% | 25 | - | $767 | $181,558 | 3 | 20th Century Fox International | false | false |
| 8 | 6 | The Wolfman | $12,654 | -62.4% | 14 | -16 | $903 | $314,541 | 4 | United International Pictures | false | false |
| 9 | 3 | Alice in Wonderland | $8,970 | -79.7% | 19 | -23 | $472 | $2,312,386 | 8 | Walt Disney Pictures | false | false |
| 10 | 10 | Everybody's Fine | $5,695 | -16.6% | 9 | +1 | $632 | $89,547 | 13 | Walt Disney Pictures | false | false |
| 11 | 8 | It's Complicated | $5,660 | -69.2% | 15 | - | $377 | $70,713 | 3 | United International Pictures | false | false |
| 12 | - | Edge of Darkness | $1,723 | - | 3 | - | $574 | $109,947 | 5 | - | false | false |
| 13 | 9 | [Rec]² | $1,645 | -77.6% | 4 | - | $411 | $82,963 | 4 | N/A | false | false |
| 14 | 12 | Did You Hear About the Morgans? | $1,262 | -68.6% | 3 | -10 | $420 | $122,036 | 5 | Sony Pictures Releasing | false | false |
| 15 | 11 | The Hurt Locker | $1,233 | -72.3% | 3 | -1 | $411 | $41,113 | 4 | N/A | false | false |
| 16 | 15 | Old Dogs | $899 | -2.5% | 2 | -3 | $449 | $635,500 | 11 | Walt Disney Pictures | false | false |
| 17 | - | Invictus | $840 | - | 3 | - | $280 | $45,704 | 10 | - | false | false |
| 18 | 13 | An Education | $599 | -53.4% | 5 | -1 | $119 | $10,705 | 3 | Sony Pictures Releasing | false | false |
| 19 | 14 | Percy Jackson & the Olympians: The Lightning Thief | $573 | -46.8% | 6 | -6 | $95 | $570,820 | 11 | 20th Century Fox International | false | false |
