| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Iron Man 2 | $1,632,582 | - | 99 | - | $16,490 | $1,632,582 | 1 | United International Pictures | true | false |
| 2 | 1 | Date Night | $44,352 | -74.1% | 17 | -8 | $2,608 | $313,870 | 2 | 20th Century Fox International | false | false |
| 3 | 2 | The Book of Eli | $26,406 | -81.1% | 8 | -12 | $3,300 | $558,387 | 3 | Sony Pictures Releasing | false | false |
| 4 | 4 | Cop Out | $17,055 | -82.7% | 12 | -14 | $1,421 | $204,393 | 2 | Warner Bros. | false | false |
| 5 | 6 | Shutter Island | $11,809 | -58.9% | 7 | +1 | $1,687 | $654,882 | 9 | United International Pictures | false | false |
| 6 | 10 | Alice in Wonderland | $11,371 | -39.8% | 5 | -3 | $2,274 | $2,073,632 | 9 | Walt Disney Pictures | false | false |
| 7 | 3 | Clash of the Titans | $9,246 | -92.1% | 10 | -52 | $924 | $3,149,214 | 5 | Warner Bros. | false | false |
| 8 | 8 | How to Train Your Dragon | $4,811 | -76.7% | 4 | -5 | $1,202 | $1,486,824 | 6 | United International Pictures | false | false |
| 9 | - | Case 39 | $3,046 | - | 2 | - | $1,523 | $119,057 | 14 | United International Pictures | false | false |
| 10 | 9 | Green Zone | $2,413 | -87.6% | 2 | -7 | $1,206 | $903,472 | 8 | United International Pictures | false | false |
| 11 | 11 | The Wolfman | $1,136 | -81.1% | 1 | - | $1,136 | $1,100,286 | 11 | United International Pictures | false | false |
| 12 | 7 | When in Rome | $1,024 | -95.5% | 3 | -11 | $341 | $309,847 | 4 | Walt Disney Pictures | false | false |
| 13 | 13 | Percy Jackson & the Olympians: The Lightning Thief | $631 | -86% | 1 | -3 | $631 | $1,553,415 | 12 | 20th Century Fox International | false | false |
| 14 | 15 | Avatar | $447 | -4.3% | 1 | - | $447 | $6,085,529 | 20 | 20th Century Fox International | false | false |
