| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Iron Man 2 | $4,701,280 | - | 581 | - | $8,091 | $4,701,280 | 1 | Paramount Pictures International | true | false |
| 2 | - | OceanWorld | $1,208,457 | - | 237 | - | $5,098 | $1,208,457 | 1 | Eagle Pictures | true | false |
| 3 | 2 | Weddings and Other Disasters | $1,060,110 | -30.1% | 305 | +3 | $3,475 | $3,096,381 | 2 | 01 Distribution | false | false |
| 4 | 1 | Clash of the Titans | $901,169 | -57.8% | 303 | -222 | $2,974 | $9,301,791 | 3 | Warner Bros. | false | false |
| 5 | - | Come Undone | $840,817 | - | 280 | - | $3,002 | $840,817 | 1 | Warner Bros. | true | false |
| 6 | - | The Last Song | $739,849 | - | 247 | - | $2,995 | $739,849 | 1 | Walt Disney Pictures | true | false |
| 7 | 5 | Basilicata Coast to Coast | $317,356 | -36.9% | 155 | -39 | $2,047 | $3,085,451 | 4 | Eagle Pictures | false | false |
| 8 | 3 | The Crazies | $310,840 | -55.8% | 187 | -96 | $1,662 | $1,242,064 | 2 | Medusa Distribuzione | false | false |
| 9 | 4 | The Ghost Writer | $253,983 | -54.6% | 106 | -182 | $2,396 | $4,210,457 | 4 | 01 Distribution | false | false |
| 10 | 7 | How to Train Your Dragon | $109,488 | -62.4% | 65 | -132 | $1,684 | $7,492,150 | 6 | Universal Pictures International (UPI) | false | false |
| 11 | 6 | Green Zone | $105,807 | -71.6% | 74 | -140 | $1,429 | $3,426,494 | 4 | Medusa Distribuzione | false | false |
| 12 | - | Vengeance | $103,128 | - | 79 | - | $1,305 | $103,128 | 1 | Fandango | true | false |
| 13 | - | Wild Grass | $100,750 | - | 31 | - | $3,250 | $100,750 | 1 | BIM Distribuzione | true | false |
| 14 | 10 | Life Is a Wonderful Thing | $77,113 | -65.2% | 51 | -65 | $1,512 | $6,161,728 | 5 | Medusa Distribuzione | false | false |
| 15 | 8 | From Paris with Love | $76,806 | -72.9% | 37 | -142 | $2,075 | $1,246,434 | 3 | N/A | false | false |
| 16 | 12 | Happy Family | $71,168 | -54.6% | 31 | -60 | $2,295 | $6,062,579 | 6 | 01 Distribution | false | false |
| 17 | 13 | Loose Cannons | $62,988 | -47.3% | 21 | -29 | $2,999 | $10,730,466 | 8 | 01 Distribution | false | false |
| 18 | 14 | Departures | $60,301 | -31% | 32 | -10 | $1,884 | $512,887 | 4 | N/A | false | false |
| 19 | 9 | The Bounty Hunter | $58,784 | -78.1% | 40 | -125 | $1,469 | $2,208,057 | 4 | Sony Pictures Releasing | false | false |
| 20 | 15 | The Concert | $54,114 | -17.5% | 17 | -24 | $3,183 | $6,137,373 | 13 | BIM Distribuzione | false | false |
| 21 | 11 | Cell 211 | $34,956 | -78.4% | 30 | -109 | $1,165 | $729,694 | 3 | N/A | false | false |
| 22 | - | Life During Wartime | $21,927 | - | 10 | - | $2,192 | $146,194 | 3 | N/A | false | false |
| 23 | 17 | Fantastic Mr. Fox | $19,546 | -66.3% | 38 | -49 | $514 | $297,811 | 3 | 20th Century Fox International | false | false |
| 24 | 19 | No One Knows About Persian Cats | $18,275 | -53.8% | 10 | -28 | $1,827 | $181,667 | 3 | BIM Distribuzione | false | false |
| 25 | 16 | Alice in Wonderland | $15,858 | -75.3% | 15 | -44 | $1,057 | $39,952,697 | 9 | Walt Disney Pictures | false | false |
| 26 | 22 | Little Nicholas | $11,436 | -53.8% | 10 | -16 | $1,143 | $876,847 | 5 | BIM Distribuzione | false | false |
| 27 | 27 | A Prophet | $10,626 | -19.6% | 10 | -4 | $1,062 | $794,872 | 7 | BIM Distribuzione | false | false |
| 28 | 25 | Avatar | $9,434 | -32.3% | 2 | -8 | $4,717 | $86,268,123 | 16 | 20th Century Fox International | false | false |
| 29 | 31 | The Man Who Will Come | $9,362 | +31.2% | 7 | -1 | $1,337 | $1,589,307 | 15 | Mikado Film | false | false |
| 30 | 23 | Simon Konianski | $8,874 | -50.4% | 7 | -7 | $1,267 | $150,872 | 4 | Fandango | false | false |
| 31 | 24 | Invictus | $8,647 | -49.5% | 7 | -5 | $1,235 | $8,302,361 | 10 | Warner Bros. | false | false |
| 32 | 21 | It's Complicated | $7,020 | -78.5% | 9 | -12 | $780 | $4,985,582 | 7 | United International Pictures | false | false |
| 33 | 30 | Extraordinary Measures | $810 | -92% | 2 | -10 | $405 | $14,921 | 2 | Sony Pictures Releasing | false | false |
