| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Toy Story 3 | $665,472 | -12.6% | 96 | - | $6,932 | $3,096,955 | 3 | Walt Disney Pictures | false | false |
| 2 | 2 | The Karate Kid | $464,768 | -25.3% | 62 | - | $7,496 | $1,564,520 | 2 | Sony Pictures Releasing | false | false |
| 3 | - | Knight and Day 2010 Re-release | $452,200 | - | 76 | - | $5,950 | $452,200 | 1 | 20th Century Fox International | true | false |
| 4 | 4 | Shrek Forever After | $389,731 | -16.1% | 91 | -6 | $4,282 | $3,178,506 | 5 | Paramount Pictures International | false | false |
| 5 | 3 | The Twilight Saga: Eclipse | $322,483 | -43.4% | 92 | -5 | $3,505 | $3,297,500 | 3 | Hoyts Distribution | false | false |
| 6 | 6 | Marmaduke | $101,945 | +11.1% | 49 | -1 | $2,080 | $424,948 | 3 | 20th Century Fox International | false | false |
| 7 | 5 | Predators | $94,624 | -50.2% | 47 | +2 | $2,013 | $363,026 | 2 | 20th Century Fox International | false | false |
| 8 | 7 | The A-Team | $32,949 | -39.8% | 29 | -17 | $1,136 | $1,468,765 | 6 | 20th Century Fox International | false | false |
| 9 | - | The Big Four | $22,753 | - | 13 | - | $1,750 | $22,753 | 1 | N/A | true | false |
| 10 | 10 | Cemetery Junction | $21,861 | -16.5% | 14 | -1 | $1,561 | $184,614 | 5 | Sony Pictures Releasing | false | false |
| 11 | 9 | Get Him to the Greek | $21,332 | -43.2% | 21 | -5 | $1,015 | $660,384 | 5 | United International Pictures | false | false |
| 12 | - | Boy | $20,282 | - | 55 | - | $368 | $6,546,377 | - | Madman Entertainment | - | false |
| 13 | 11 | The Last Station 2010 Re-release | $19,556 | -20.1% | 22 | -7 | $888 | $670,127 | 7 | Rialto Distribution | false | false |
| 14 | 14 | My One and Only | $10,566 | -4% | 14 | +3 | $754 | $32,019 | 2 | Madman Entertainment | false | false |
| 15 | 13 | Me and Orson Welles | $10,455 | -27.2% | 26 | +2 | $402 | $65,014 | 3 | Madman Entertainment | false | false |
| 16 | 15 | The Secret in Their Eyes | $9,600 | -5.8% | 12 | - | $800 | $389,428 | 10 | Rialto Distribution | false | false |
| 17 | 12 | Sex and the City 2 | $7,614 | -47.4% | 26 | -15 | $292 | $1,698,051 | 7 | Roadshow Films | false | false |
| 18 | 16 | Welcome | $6,900 | +42.9% | 5 | -13 | $1,380 | $33,734 | 3 | Palace Films | false | false |
| 19 | - | The Blind Side | $4,566 | - | 16 | - | $285 | $1,236,319 | 11 | Warner Bros. | false | false |
| 20 | 17 | A Single Man | $3,546 | -23.6% | 14 | -5 | $253 | $444,243 | 11 | Icon Film Distribution | false | false |
| 21 | 25 | Home by Christmas | $2,399 | +215.7% | 7 | +1 | $342 | $803,733 | 13 | - | false | false |
| 22 | 19 | I Hate Luv Storys | $1,991 | -45.7% | 1 | -1 | $1,991 | $21,802 | 3 | Mind Blowing Films | false | false |
| 23 | 20 | Coco Chanel & Igor Stravinsky | $1,669 | -20.3% | 11 | +1 | $151 | $109,083 | 7 | Madman Entertainment | false | false |
| 24 | 23 | Letters to Juliet | $1,570 | +2.2% | 5 | +1 | $314 | $335,435 | 10 | Hoyts Distribution | false | false |
| 25 | 21 | With or Without You | $1,410 | -31.1% | 5 | - | $282 | $64,370 | 22 | - | false | false |
| 26 | 18 | Prince of Persia: The Sands of Time | $1,133 | -71.5% | 9 | -25 | $125 | $1,301,715 | 8 | Walt Disney Pictures | false | false |
| 27 | - | The Hedgehog | $1,038 | - | 5 | - | $207 | $89,105 | 12 | Madman Entertainment | false | false |
| 28 | 22 | Micmacs | $971 | -38.5% | 5 | - | $194 | $55,859 | 6 | Hopscotch Films | false | false |
| 29 | 24 | Milenge Milenge | $676 | -36.8% | 1 | - | $676 | $2,523 | 2 | N/A | false | false |
| 30 | 29 | Brothers | $476 | +11.7% | 1 | - | $476 | $3,896 | 10 | Roadshow Films | false | false |
| 31 | 27 | Mao's Last Dancer | $424 | -29.6% | 4 | +1 | $106 | $1,405,904 | 20 | Hopscotch Films | false | false |
| 32 | 30 | The Hurt Locker | $351 | +6.7% | 2 | - | $175 | $410,646 | 16 | Roadshow Films | false | false |
| 33 | - | The Way 2010 Re-release | $340 | - | 1 | - | $340 | $4,824 | 9 | Madman Entertainment | false | false |
| 34 | 26 | Nowhere Boy | $230 | -69.3% | 1 | -2 | $230 | $152,723 | 17 | Madman Entertainment | false | false |
| 35 | - | A Nightmare on Elm Street | $75 | - | 1 | - | $75 | $246,469 | 8 | Warner Bros. | false | false |
| 36 | 31 | The Road | $26 | -79% | 1 | - | $26 | $147,237 | 18 | Hoyts Distribution | false | false |
