| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Inception | $729,868 | - | 87 | - | $8,389 | $729,868 | 1 | Warner Bros. | true | false |
| 2 | 3 | Knight and Day 2010 Re-release | $192,951 | -57.3% | 73 | -3 | $2,643 | $783,515 | 2 | 20th Century Fox International | false | false |
| 3 | 1 | Toy Story 3 | $187,080 | -71.9% | 96 | - | $1,948 | $3,427,713 | 4 | Walt Disney Pictures | false | false |
| 4 | 2 | The Karate Kid | $145,463 | -68.7% | 61 | -1 | $2,384 | $1,813,310 | 3 | Sony Pictures Releasing | false | false |
| 5 | 5 | The Twilight Saga: Eclipse | $138,276 | -57.1% | 74 | -18 | $1,868 | $3,597,576 | 4 | Hoyts Distribution | false | false |
| 6 | - | The Girl Who Played with Fire | $87,514 | - | 30 | - | $2,917 | $87,514 | - | Rialto Distribution | - | false |
| 7 | 4 | Shrek Forever After | $82,330 | -78.9% | 90 | -1 | $914 | $3,366,662 | 6 | Paramount Pictures International | false | false |
| 8 | 7 | Predators | $37,497 | -60.4% | 43 | -4 | $872 | $450,165 | 3 | 20th Century Fox International | false | false |
| 9 | - | London Assurance | $30,427 | - | 13 | - | $2,340 | $30,427 | 1 | Rialto Distribution | true | false |
| 10 | 6 | Marmaduke | $19,460 | -80.9% | 47 | -2 | $414 | $459,387 | 4 | 20th Century Fox International | false | false |
| 11 | 13 | The Last Station 2010 Re-release | $18,654 | -4.6% | 22 | - | $847 | $714,646 | 8 | Rialto Distribution | false | false |
| 12 | - | Aftershock | $16,030 | - | 3 | - | $5,343 | $16,030 | 1 | N/A | true | false |
| 13 | 10 | Cemetery Junction | $15,550 | -28.9% | 14 | - | $1,110 | $212,940 | 6 | Sony Pictures Releasing | false | false |
| 14 | - | Khatta Meetha | $13,705 | - | 4 | - | $3,426 | $13,705 | 1 | - | true | false |
| 15 | - | Boy | $13,549 | - | 43 | - | $315 | $6,723,124 | - | Madman Entertainment | - | false |
| 16 | 8 | The A-Team | $11,133 | -66.2% | 21 | -8 | $530 | $1,525,366 | 7 | 20th Century Fox International | false | false |
| 17 | 11 | Get Him to the Greek | $10,778 | -49.5% | 17 | -4 | $634 | $699,741 | 6 | United International Pictures | false | false |
| 18 | 16 | The Secret in Their Eyes | $9,196 | -4.2% | 12 | - | $766 | $413,956 | 11 | Rialto Distribution | false | false |
| 19 | 15 | Me and Orson Welles | $7,133 | -31.8% | 25 | -1 | $285 | $79,665 | 4 | Madman Entertainment | false | false |
| 20 | 14 | My One and Only | $6,871 | -35% | 13 | -1 | $528 | $44,480 | 3 | Madman Entertainment | false | false |
| 21 | 18 | Welcome | $6,306 | -8.6% | 5 | - | $1,261 | $42,993 | 4 | Palace Films | false | false |
| 22 | 19 | The Blind Side | $4,213 | -7.7% | 16 | - | $263 | $1,272,759 | 12 | Warner Bros. | false | false |
| 23 | 17 | Sex and the City 2 | $4,004 | -47.4% | 26 | - | $154 | $1,745,121 | 8 | Roadshow Films | false | false |
| 24 | 20 | A Single Man | $3,619 | +2.1% | 12 | -2 | $301 | $460,104 | 12 | Icon Film Distribution | false | false |
| 25 | 23 | Coco Chanel & Igor Stravinsky | $1,116 | -33.1% | 10 | -1 | $111 | $113,984 | 8 | Madman Entertainment | false | false |
| 26 | 27 | The Hedgehog | $893 | -14% | 5 | - | $178 | $92,614 | 13 | Madman Entertainment | false | false |
| 27 | 25 | With or Without You | $866 | -38.6% | 3 | -2 | $288 | $67,781 | 23 | - | false | false |
| 28 | 24 | Letters to Juliet | $575 | -63.4% | 5 | - | $115 | $345,242 | 11 | Hoyts Distribution | false | false |
| 29 | 26 | Prince of Persia: The Sands of Time | $513 | -54.7% | 6 | -3 | $85 | $1,333,445 | 9 | Walt Disney Pictures | false | false |
| 30 | 22 | I Hate Luv Storys | $512 | -74.3% | 1 | - | $512 | $23,475 | 4 | Mind Blowing Films | false | false |
| 31 | 28 | Micmacs | $464 | -52.2% | 5 | - | $92 | $58,514 | 7 | Hopscotch Films | false | false |
| 32 | 31 | Mao's Last Dancer | $426 | +0.5% | 4 | - | $106 | $1,439,222 | 21 | Hopscotch Films | false | false |
| 33 | 33 | The Way 2010 Re-release | $205 | -39.7% | 1 | - | $205 | $5,313 | 10 | Madman Entertainment | false | false |
| 34 | 30 | Brothers | $186 | -60.9% | 1 | - | $186 | $4,808 | 11 | Roadshow Films | false | false |
| 35 | 34 | Nowhere Boy | $24 | -89.6% | 1 | - | $24 | $156,594 | 18 | Madman Entertainment | false | false |
