| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Cats & Dogs: The Revenge of Kitty Galore | $339,399 | - | 78 | - | $4,351 | $339,399 | 1 | Warner Bros. | true | false |
| 2 | 1 | Despicable Me | $255,913 | -27.5% | 56 | -14 | $4,569 | $698,576 | 2 | United International Pictures | false | false |
| 3 | 2 | Shrek Forever After | $196,157 | -41.4% | 58 | -24 | $3,382 | $5,774,959 | 5 | United International Pictures | false | false |
| 4 | 4 | The Karate Kid | $145,975 | -29.3% | 42 | -4 | $3,475 | $910,320 | 3 | Sony Pictures Releasing | false | false |
| 5 | 3 | Toy Story 3 | $136,445 | -39.7% | 47 | -11 | $2,903 | $7,973,765 | 8 | Walt Disney Pictures | false | false |
| 6 | 5 | Predators | $86,805 | -41.7% | 31 | -1 | $2,800 | $289,151 | 2 | 20th Century Fox International | false | false |
| 7 | 6 | The Sorcerer's Apprentice | $66,281 | -51.7% | 28 | -16 | $2,367 | $1,250,319 | 4 | Walt Disney Pictures | false | false |
| 8 | - | The Back-up Plan | $62,706 | - | 28 | - | $2,239 | $62,706 | 1 | Sony Pictures Releasing | true | false |
| 9 | 8 | Letters to Juliet | $24,239 | -26% | 9 | - | $2,693 | $67,163 | 2 | N/A | false | false |
| 10 | - | A Single Man | $20,501 | - | 7 | - | $2,928 | $20,501 | 1 | N/A | true | false |
| 11 | - | The White Ribbon | $18,356 | - | 7 | - | $2,622 | $18,356 | 1 | N/A | true | false |
| 12 | 7 | The Twilight Saga: Eclipse | $14,123 | -77.3% | 11 | -23 | $1,283 | $2,975,043 | 6 | Cine Colombia | false | false |
| 13 | 9 | Knight and Day 2010 Re-release | $10,653 | -60.6% | 5 | -8 | $2,130 | $391,024 | 4 | 20th Century Fox International | false | false |
| 14 | 11 | The Road | $1,004 | -70.3% | 1 | - | $1,004 | $184,317 | 7 | N/A | false | false |
