| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Last Airbender | $448,256 | - | 80 | - | $5,603 | $448,256 | 1 | United International Pictures | true | false |
| 2 | 1 | Inception | $311,296 | -30.4% | 68 | -4 | $4,577 | $933,236 | 2 | Warner Bros. | false | false |
| 3 | 3 | Despicable Me | $76,112 | -50.5% | 40 | -25 | $1,902 | $1,002,925 | 4 | United International Pictures | false | false |
| 4 | 2 | Cats & Dogs: The Revenge of Kitty Galore | $68,029 | -55.7% | 41 | -24 | $1,659 | $644,074 | 3 | Warner Bros. | false | false |
| 5 | 5 | The Karate Kid | $37,614 | -53.1% | 31 | -11 | $1,213 | $1,078,394 | 5 | Sony Pictures Releasing | false | false |
| 6 | 6 | Shrek Forever After | $31,467 | -56.2% | 28 | -17 | $1,123 | $5,934,157 | 7 | United International Pictures | false | false |
| 7 | - | Brothers | $25,538 | - | 15 | - | $1,702 | $25,538 | 1 | N/A | true | false |
| 8 | 7 | Toy Story 3 | $19,842 | -61.4% | 26 | -6 | $763 | $8,086,592 | 10 | Walt Disney Pictures | false | false |
| 9 | 9 | Predators | $11,489 | -63.9% | 22 | -9 | $522 | $371,612 | 4 | 20th Century Fox International | false | false |
| 10 | 10 | The Back-up Plan | $11,170 | -57.3% | 13 | -12 | $859 | $128,474 | 3 | Sony Pictures Releasing | false | false |
| 11 | 12 | Letters to Juliet | $10,727 | -27.6% | 5 | -1 | $2,145 | $103,499 | 4 | N/A | false | false |
| 12 | - | The Last Song | $10,523 | - | 7 | - | $1,503 | $13,824 | 1 | Walt Disney Pictures | true | false |
| 13 | 11 | The Sorcerer's Apprentice | $6,532 | -70.9% | 10 | -11 | $653 | $1,302,770 | 6 | Walt Disney Pictures | false | false |
| 14 | 14 | The White Ribbon | $4,700 | -46.4% | 4 | - | $1,175 | $39,508 | 3 | N/A | false | false |
| 15 | 18 | The Twilight Saga: Eclipse | $1,645 | -47.3% | 1 | - | $1,645 | $2,986,716 | 8 | Cine Colombia | false | false |
| 16 | 15 | A Single Man | $1,508 | -82.2% | 1 | -3 | $1,508 | $36,136 | 3 | N/A | false | false |
