| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Cats & Dogs: The Revenge of Kitty Galore | $152,231 | - | 46 | - | $3,309 | $152,231 | 1 | Warner Bros. | true | false |
| 2 | 1 | The Last Airbender | $142,012 | -65.8% | 60 | - | $2,366 | $2,776,785 | 3 | United International Pictures | false | false |
| 3 | 2 | Salt | $87,363 | -66.5% | 60 | - | $1,456 | $2,513,996 | 4 | Sony Pictures Releasing | false | false |
| 4 | 3 | The Back-up Plan | $18,732 | -67.5% | 16 | - | $1,170 | $106,248 | 2 | Sony Pictures Releasing | false | false |
| 5 | 5 | Inception | $13,028 | -63.1% | 12 | -16 | $1,085 | $2,371,117 | 6 | Warner Bros. | false | false |
| 6 | 4 | The Sorcerer's Apprentice | $9,331 | -74.8% | 11 | +7 | $848 | $1,901,208 | 5 | Walt Disney Pictures | false | false |
| 7 | 6 | The Karate Kid | $5,346 | -41.3% | 4 | -2 | $1,336 | $3,334,260 | 11 | Sony Pictures Releasing | false | false |
| 8 | 8 | Prince of Persia: The Sands of Time | $4,395 | +95.3% | 1 | - | $4,395 | $4,126,158 | 13 | Walt Disney Pictures | false | false |
| 9 | 7 | Despicable Me | $1,975 | -60.8% | 3 | -5 | $658 | $1,500,595 | 7 | United International Pictures | false | false |
