| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Cats & Dogs: The Revenge of Kitty Galore | $267,549 | -42.6% | 66 | - | $4,053 | $854,015 | 2 | Warner Bros. | false | false |
| 2 | - | Grown Ups | $166,759 | - | 40 | - | $4,168 | $166,759 | 1 | Sony Pictures Releasing | true | false |
| 3 | - | Predators | $162,029 | - | 37 | - | $4,379 | $162,029 | 1 | 20th Century Fox International | true | false |
| 4 | 2 | The Karate Kid | $103,579 | -49.1% | 43 | - | $2,408 | $919,595 | 3 | Sony Pictures Releasing | false | false |
| 5 | 3 | Despicable Me | $65,767 | -58.9% | 62 | - | $1,060 | $2,353,971 | 4 | Universal Pictures International (UPI) | false | false |
| 6 | - | Letters to Juliet | $59,106 | - | 25 | - | $2,364 | $61,145 | 1 | Venus | true | false |
| 7 | - | The Haunting of Molly Hartley | $57,292 | - | 20 | - | $2,864 | $57,292 | 1 | N/A | true | false |
| 8 | 4 | Inception | $48,103 | -48% | 52 | - | $925 | $927,448 | 4 | Warner Bros. | false | false |
| 9 | 7 | The Rebound | $33,909 | -46% | 15 | - | $2,260 | $125,841 | 2 | N/A | false | false |
| 10 | - | Pope Joan | $25,883 | - | 14 | - | $1,848 | $25,883 | 1 | N/A | true | false |
| 11 | 5 | The Sorcerer's Apprentice | $17,251 | -74.1% | 43 | - | $401 | $1,268,583 | 5 | Walt Disney Pictures | false | false |
| 12 | 6 | Dorothy Mills | $14,335 | -77.3% | 25 | - | $573 | $295,682 | 3 | N/A | false | false |
| 13 | 8 | Messengers 2: The Scarecrow | $6,290 | -86% | 18 | - | $349 | $73,225 | 2 | N/A | false | false |
| 14 | 10 | Shrek Forever After | $3,827 | -82.2% | 53 | -24 | $72 | $4,079,939 | 7 | Paramount Pictures International | false | false |
| 15 | 9 | Kick-Ass | $1,854 | -94.5% | 20 | - | $92 | $49,544 | 2 | Universal Pictures International (UPI) | false | false |
| 16 | 11 | The Twilight Saga: Eclipse | $1,543 | -86.3% | 67 | - | $23 | $2,324,490 | 6 | N/A | false | false |
| 17 | - | Dear John | $905 | - | 2 | - | $452 | $137,351 | 18 | Sony Pictures Releasing | false | false |
| 18 | - | The Last Song | $738 | - | 13 | - | $56 | $100,732 | 12 | Walt Disney Pictures | false | false |
| 19 | - | The Back-up Plan | $671 | - | 1 | - | $671 | $357,319 | 9 | Sony Pictures Releasing | false | false |
| 20 | 17 | The Book of Eli | $520 | -28.5% | 1 | - | $520 | $270,104 | 20 | Sony Pictures Releasing | false | false |
| 21 | 16 | Toy Story 3 | $53 | -95.1% | 53 | - | $1 | $3,753,051 | 10 | Walt Disney Pictures | false | false |
