| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Last Airbender | $9,467 | - | 6 | - | $1,577 | $13,468 | 1 | United International Pictures | true | false |
| 2 | 1 | Salt | $5,486 | -54.1% | 7 | - | $783 | $53,802 | 3 | Sony Pictures Releasing | false | false |
| 3 | 3 | Inception | $4,754 | -28.7% | 6 | +2 | $792 | $106,949 | 5 | Warner Bros. | false | false |
| 4 | 2 | Predators | $3,510 | -51% | 7 | - | $501 | $18,771 | 2 | 20th Century Fox International | false | false |
| 5 | - | Letters to Juliet | $2,988 | - | 4 | - | $747 | $3,934 | 1 | N/A | true | false |
| 6 | 8 | Shrek Forever After | $2,485 | +38.4% | 7 | - | $355 | $156,896 | 13 | United International Pictures | false | false |
| 7 | 5 | Sex and the City 2 | $2,242 | -15.2% | 9 | - | $249 | $366,221 | 12 | Warner Bros. | false | false |
| 8 | 12 | The Twilight Saga: Eclipse | $1,562 | +56.7% | 5 | - | $312 | $90,685 | 8 | N/A | false | false |
| 9 | 4 | Cats & Dogs: The Revenge of Kitty Galore | $1,560 | -59% | 9 | - | $173 | $20,223 | 3 | Warner Bros. | false | false |
| 10 | 6 | Killers | $1,101 | -52.5% | 3 | - | $367 | $63,256 | 7 | N/A | false | false |
| 11 | 11 | Prince of Persia: The Sands of Time | $976 | -25.2% | 6 | - | $162 | $152,365 | 12 | Walt Disney Pictures | false | false |
| 12 | 9 | The Sorcerer's Apprentice | $931 | -47.3% | 4 | - | $232 | $48,868 | 6 | United International Pictures | false | false |
| 13 | 7 | Knight and Day 2010 Re-release | $875 | -56.1% | 7 | - | $125 | $30,550 | 4 | 20th Century Fox International | false | false |
| 14 | 13 | Toy Story 3 | $728 | -10% | 7 | - | $104 | $66,704 | 10 | Walt Disney Pictures | false | false |
| 15 | 10 | A Nightmare on Elm Street | $653 | -51% | 6 | - | $108 | $57,494 | 10 | Warner Bros. | false | false |
| 16 | 15 | The Back-up Plan | $308 | -50.1% | 1 | -1 | $308 | $57,585 | 10 | Sony Pictures Releasing | false | false |
| 17 | 14 | When You're Strange | $269 | -65.1% | 1 | - | $269 | $7,957 | 4 | N/A | false | false |
| 18 | 19 | The A-Team | $164 | +8,100% | 6 | - | $27 | $10,724 | 7 | 20th Century Fox International | false | false |
| 19 | 17 | Robin Hood | $133 | +3.1% | 7 | - | $19 | $161,466 | 15 | United International Pictures | false | false |
| 20 | 16 | Get Him to the Greek | $89 | -80.3% | 4 | - | $22 | $14,420 | 5 | United International Pictures | false | false |
| 21 | - | Date Night | $74 | - | 7 | - | $10 | $26,788 | 14 | 20th Century Fox International | false | false |
