| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Salt | $2,262,658 | -35.8% | 365 | - | $6,199 | $7,102,588 | 2 | Sony Pictures Releasing | false | false |
| 2 | - | Vampires Suck | $1,299,711 | - | 179 | - | $7,260 | $1,299,711 | 1 | 20th Century Fox International | true | false |
| 3 | 2 | Inception | $1,222,206 | -26.2% | 344 | -35 | $3,552 | $28,725,194 | 6 | Warner Bros. | false | false |
| 4 | 3 | The Expendables | $934,487 | -38.1% | 219 | -5 | $4,267 | $6,756,013 | 3 | Roadshow Films | false | false |
| 5 | - | Piranha 3D | $812,540 | - | 141 | - | $5,762 | $833,797 | 1 | Roadshow Films | true | false |
| 6 | 4 | Step Up 3D | $655,430 | -40.6% | 214 | -46 | $3,062 | $8,347,817 | 4 | Universal Pictures International (UPI) | false | false |
| 7 | 5 | Scott Pilgrim vs. the World | $412,968 | -26.8% | 175 | -2 | $2,359 | $2,373,343 | 3 | Universal Pictures International (UPI) | false | false |
| 8 | - | Avatar | $256,387 | - | 142 | - | $1,805 | $103,521,588 | 37 | 20th Century Fox International | false | false |
| 9 | - | Boy | $247,397 | - | 41 | - | $6,034 | $320,589 | 1 | Paramount Pictures International | true | false |
| 10 | 6 | The Ghost Writer | $233,273 | -21.3% | 77 | +1 | $3,029 | $1,584,258 | 3 | Hoyts Distribution | false | false |
| 11 | 8 | Matching Jack | $170,501 | -26.2% | 186 | - | $916 | $553,424 | 2 | 20th Century Fox International | false | false |
| 12 | 7 | Killers | $106,000 | -54.5% | 119 | -95 | $890 | $5,025,829 | 5 | Roadshow Films | false | false |
| 13 | - | Toy Story 3 | $83,890 | - | 70 | - | $1,198 | $37,957,715 | - | Walt Disney Pictures | - | false |
| 14 | - | The Killer Inside Me | $80,325 | - | 31 | - | $2,591 | $88,673 | 1 | Hopscotch Films | true | false |
| 15 | - | Father of My Children | $68,541 | - | 17 | - | $4,031 | $121,311 | 1 | Palace Films | true | false |
| 16 | 14 | Cairo Time | $59,981 | +24.1% | 13 | +1 | $4,613 | $153,719 | 2 | Paramount Pictures International | false | false |
| 17 | - | The Kids Are All Right | $52,932 | - | 55 | - | $962 | $52,932 | - | Hopscotch Films | - | false |
| 18 | 12 | Hubble | $51,682 | -6.4% | 5 | - | $10,336 | $241,481 | 3 | IMAX | false | false |
| 19 | 13 | Four Lions | $40,306 | -20% | 11 | - | $3,664 | $176,628 | 2 | Hopscotch Films | false | false |
| 20 | 11 | Knight and Day 2010 Re-release | $36,420 | -55.6% | 50 | -50 | $728 | $9,075,731 | 7 | 20th Century Fox International | false | false |
| 21 | - | Aashayein | $3,836 | - | 6 | - | $639 | $3,836 | 1 | Mind Blowing Films | true | false |
