| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Cats & Dogs: The Revenge of Kitty Galore | $147,441 | -3.1% | 46 | - | $3,205 | $375,312 | 2 | Warner Bros. | false | false |
| 2 | - | Grown Ups | $144,606 | - | 15 | - | $9,640 | $156,587 | 1 | Sony Pictures Releasing | true | false |
| 3 | 2 | The Last Airbender | $66,164 | -53.4% | 43 | -17 | $1,538 | $2,901,003 | 4 | United International Pictures | false | false |
| 4 | 3 | Salt | $32,747 | -62.5% | 37 | -23 | $885 | $2,559,958 | 5 | Sony Pictures Releasing | false | false |
| 5 | - | The Book of Eli | $10,548 | - | 4 | - | $2,637 | $579,264 | 20 | Sony Pictures Releasing | false | false |
| 6 | 5 | Inception | $5,140 | -60.5% | 5 | -7 | $1,028 | $2,382,426 | 7 | Warner Bros. | false | false |
| 7 | 8 | Prince of Persia: The Sands of Time | $3,281 | -25.3% | 2 | +1 | $1,640 | $4,132,329 | 14 | Walt Disney Pictures | false | false |
| 8 | 6 | The Sorcerer's Apprentice | $3,022 | -67.6% | 4 | -7 | $755 | $1,916,630 | 6 | Walt Disney Pictures | false | false |
| 9 | 9 | Despicable Me | $2,552 | +29.2% | 4 | +1 | $638 | $1,504,707 | 8 | United International Pictures | false | false |
| 10 | 7 | The Karate Kid | $2,392 | -55.3% | 4 | - | $598 | $3,337,968 | 12 | Sony Pictures Releasing | false | false |
| 11 | 4 | The Back-up Plan | $1,635 | -91.3% | 16 | - | $102 | $109,744 | 3 | Sony Pictures Releasing | false | false |
