| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Expendables | $53,732 | - | 4 | - | $13,433 | $99,142 | 1 | N/A | true | false |
| 2 | - | Cats & Dogs: The Revenge of Kitty Galore | $17,344 | - | 6 | - | $2,890 | $21,348 | 1 | Warner Bros. | true | false |
| 3 | 1 | Salt | $15,971 | -69.7% | 6 | -1 | $2,661 | $123,898 | 2 | Sony Pictures Releasing | false | false |
| 4 | 2 | Inception | $9,565 | -60.6% | 5 | - | $1,913 | $434,503 | 5 | Warner Bros. | false | false |
| 5 | - | Letters to Juliet | $9,391 | - | 4 | - | $2,347 | $15,871 | 1 | N/A | true | false |
| 6 | 4 | Shrek Forever After | $6,462 | -56.9% | 5 | -4 | $1,292 | $283,510 | 6 | United International Pictures | false | false |
| 7 | - | Vampires Suck | $6,294 | - | 3 | - | $2,098 | $10,019 | 1 | 20th Century Fox International | true | false |
| 8 | 3 | The Last Airbender | $5,996 | -69.1% | 5 | - | $1,199 | $51,171 | 2 | United International Pictures | false | false |
| 9 | 5 | The Karate Kid | $5,269 | -54% | 4 | - | $1,317 | $126,246 | 4 | Sony Pictures Releasing | false | false |
| 10 | 6 | The Sorcerer's Apprentice | $3,735 | -65.9% | 5 | - | $747 | $82,465 | 3 | Walt Disney Pictures | false | false |
| 11 | 7 | Toy Story 3 | $2,593 | -56.8% | 3 | -1 | $864 | $418,232 | 10 | Walt Disney Pictures | false | false |
| 12 | 8 | The Ugly Duckling and Me! | $675 | -79.6% | 3 | -1 | $225 | $7,202 | 3 | N/A | false | false |
| 13 | 10 | Grown Ups | $333 | -76.5% | 1 | - | $333 | $135,743 | 9 | Sony Pictures Releasing | false | false |
| 14 | 11 | Babies | $290 | -79.2% | 1 | - | $290 | $24,917 | 5 | N/A | false | false |
| 15 | 9 | Knight and Day 2010 Re-release | $271 | -86% | 6 | +3 | $45 | $112,379 | 7 | 20th Century Fox International | false | false |
| 16 | 12 | 22 Bullets | $152 | -85.8% | 1 | - | $152 | $11,238 | 3 | N/A | false | false |
