| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Step Up 3D | $417,558 | -28.6% | 74 | +1 | $5,642 | $1,183,275 | 2 | NuMetro Distribution | false | false |
| 2 | - | The A-Team | $188,226 | - | 62 | - | $3,035 | $188,226 | 1 | 20th Century Fox International | true | false |
| 3 | 2 | Grown Ups | $132,361 | -24.2% | 65 | - | $2,036 | $843,364 | 3 | Sony Pictures Releasing | false | false |
| 4 | 3 | Inception | $112,905 | -22.6% | 60 | -1 | $1,881 | $1,060,249 | 4 | Warner Bros. | false | false |
| 5 | 4 | Shrek Forever After | $76,629 | -27.1% | 64 | -13 | $1,197 | $3,019,259 | 6 | United International Pictures | false | false |
| 6 | 5 | Cats & Dogs: The Revenge of Kitty Galore | $74,072 | -17.6% | 66 | -5 | $1,122 | $470,547 | 3 | Warner Bros. | false | false |
| 7 | 6 | Knight and Day 2010 Re-release | $62,381 | -29.4% | 68 | -2 | $917 | $1,229,046 | 5 | 20th Century Fox International | false | false |
| 8 | - | Furry Vengeance | $33,047 | - | 35 | - | $944 | $33,047 | 1 | NuMetro Distribution | true | false |
| 9 | 7 | Mao's Last Dancer | $32,246 | -13.2% | 14 | -1 | $2,303 | $169,094 | 3 | NuMetro Distribution | false | false |
| 10 | 9 | Death at a Funeral | $9,231 | -35.7% | 16 | -4 | $576 | $1,055,199 | 10 | Sony Pictures Releasing | false | false |
| 11 | - | London River 2010 Re-release | $8,202 | - | 7 | - | $1,171 | $8,202 | 1 | United International Pictures | true | false |
| 12 | - | The Unforgiving | $7,202 | - | 14 | - | $514 | $7,202 | 1 | N/A | true | false |
| 13 | 11 | Please Give | $6,682 | -31.2% | 7 | - | $954 | $20,987 | 2 | Sony Pictures Releasing | false | false |
| 14 | 10 | Toy Story 3 | $6,655 | -40.5% | 8 | -13 | $831 | $3,271,350 | 9 | Walt Disney Pictures | false | false |
| 15 | 13 | Schuks Tshabalala's Survival Guide to South Africa | $3,349 | -46.7% | 8 | -9 | $418 | $5,138,703 | 13 | N/A | false | false |
| 16 | 14 | The White Ribbon | $2,581 | -52% | 4 | -2 | $645 | $35,980 | 4 | United International Pictures | false | false |
| 17 | 15 | The Boys Are Back | $2,249 | -41.8% | 5 | -1 | $449 | $103,311 | 7 | N/A | false | false |
| 18 | 12 | She's Out of My League | $2,193 | -73.1% | 9 | -15 | $243 | $651,192 | 9 | United International Pictures | false | false |
| 19 | 17 | Broken Embraces | $1,278 | -27.7% | 3 | - | $426 | $83,834 | 10 | Ster-Kinekor Pictures | false | false |
| 20 | 18 | Themba | $596 | -22% | 3 | - | $198 | $20,272 | 6 | N/A | false | false |
| 21 | 16 | Shirley Adams | $595 | -81.1% | 3 | -7 | $198 | $5,995 | 2 | N/A | false | false |
