| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | The Last Airbender | $342,829 | -47.7% | 87 | +2 | $3,940 | $2,643,189 | 3 | Universal Pictures International (UPI) | false | false |
| 2 | 3 | Inception | $280,626 | -33.8% | 104 | -3 | $2,698 | $7,528,632 | 7 | Warner Bros. | false | false |
| 3 | - | Piranha 3D | $276,702 | - | 56 | - | $4,941 | $304,728 | 1 | A-Film Distribution | true | false |
| 4 | 2 | The Expendables | $259,865 | -49.5% | 91 | - | $2,855 | $1,975,724 | 3 | Benelux Film Distributors | false | false |
| 5 | 4 | Step Up 3D | $235,682 | -39.5% | 91 | -1 | $2,589 | $3,890,930 | 5 | Independent Films | false | false |
| 6 | 5 | Dinner for Schmucks | $160,567 | -37.5% | 49 | - | $3,276 | $565,052 | 2 | Universal Pictures International (UPI) | false | false |
| 7 | 6 | Salt | $143,839 | -36.5% | 78 | -1 | $1,844 | $2,613,778 | 5 | Sony Pictures Releasing | false | false |
| 8 | 8 | Vampires Suck | $75,971 | -51.2% | 48 | - | $1,582 | $297,906 | 2 | Warner Bros. | false | false |
| 9 | 9 | Marmaduke | $69,292 | -55.3% | 81 | +2 | $855 | $1,140,544 | 4 | Warner Bros. | false | false |
| 10 | 13 | The Secret in Their Eyes | $60,733 | -24.8% | 13 | - | $4,671 | $188,027 | 2 | Wild Bunch Distribution | false | false |
| 11 | 7 | Shrek Forever After | $59,899 | -62.4% | 127 | -6 | $471 | $6,707,188 | 9 | Universal Pictures International (UPI) | false | false |
| 12 | 12 | I Am Love | $59,317 | -33.9% | 16 | +2 | $3,707 | $198,533 | 2 | Cinéart | false | false |
| 13 | 10 | Toy Story 3 | $55,977 | -61.5% | 115 | -8 | $486 | $5,429,854 | 11 | Walt Disney Pictures | false | false |
| 14 | 11 | A Turtle's Tale: Sammy's Adventures | $54,249 | -54.5% | 90 | -2 | $602 | $1,369,402 | 5 | Universal Pictures International (UPI) | false | false |
| 15 | 14 | The Karate Kid | $36,267 | -54.7% | 75 | -3 | $483 | $3,695,102 | 7 | Sony Pictures Releasing | false | false |
| 16 | 16 | Knight and Day 2010 Re-release | $34,940 | -46.4% | 50 | -9 | $698 | $3,154,768 | 8 | Warner Bros. | false | false |
| 17 | 15 | Cats & Dogs: The Revenge of Kitty Galore | $28,930 | -57.4% | 80 | -8 | $361 | $1,198,887 | 6 | Warner Bros. | false | false |
| 18 | 17 | The Sorcerer's Apprentice | $27,936 | -51.7% | 54 | -16 | $517 | $1,806,283 | 6 | Walt Disney Pictures | false | false |
| 19 | 18 | Sterke verhalen | $27,071 | -46.8% | 30 | -2 | $902 | $262,950 | 3 | A-Film Distribution | false | false |
| 20 | - | The Round Up | $17,269 | - | 20 | - | $863 | $18,679 | 1 | N/A | true | false |
