| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Resident Evil: Afterlife | $87,204 | - | 15 | - | $5,813 | $87,204 | 1 | Sony Pictures Releasing | true | false |
| 2 | 2 | Cats & Dogs: The Revenge of Kitty Galore | $19,934 | -50.7% | 11 | -1 | $1,812 | $209,850 | 4 | Warner Bros. | false | false |
| 3 | 1 | The Last Airbender | $16,486 | -67.4% | 13 | +2 | $1,268 | $178,015 | 3 | Paramount Pictures International | false | false |
| 4 | 3 | Grown Ups | $9,845 | -14.8% | 6 | +1 | $1,640 | $114,342 | 5 | Sony Pictures Releasing | false | false |
| 5 | - | Letters to Juliet | $5,279 | - | 4 | - | $1,319 | $5,279 | 1 | - | true | false |
| 6 | 4 | Salt | $5,256 | -51.1% | 7 | - | $750 | $78,625 | 4 | Sony Pictures Releasing | false | false |
| 7 | 5 | Inception | $5,085 | -49.7% | 5 | -1 | $1,017 | $151,717 | 6 | Warner Bros. | false | false |
| 8 | 6 | My Best Friend's Girl | $4,216 | -50.5% | 5 | -1 | $843 | $15,781 | 2 | - | false | false |
| 9 | 7 | Despicable Me | $2,836 | -50.8% | 6 | -2 | $472 | $257,830 | 7 | Universal Pictures International (UPI) | false | false |
| 10 | - | Igor | $1,908 | - | 2 | - | $954 | $1,908 | 1 | - | true | false |
| 11 | 9 | The Sorcerer's Apprentice | $1,877 | -31.5% | 5 | +1 | $375 | $250,538 | 9 | Walt Disney Pictures | false | false |
| 12 | 8 | Undertow | $1,688 | -52.2% | 4 | -1 | $422 | $7,773 | 2 | N/A | false | false |
| 13 | 11 | Two Lovers | $706 | -66.8% | 3 | - | $235 | $10,091 | 3 | - | false | false |
| 14 | 10 | Predators | $521 | -80.3% | 2 | -1 | $260 | $81,431 | 6 | 20th Century Fox International | false | false |
