| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Grown Ups | $68,484 | -24.1% | 15 | - | $4,565 | $353,424 | 3 | Sony Pictures Releasing | false | false |
| 2 | 2 | Cats & Dogs: The Revenge of Kitty Galore | $27,269 | -56.8% | 13 | -17 | $2,097 | $548,950 | 4 | Warner Bros. | false | false |
| 3 | 3 | The Last Airbender | $6,844 | -79.2% | 6 | -21 | $1,140 | $2,963,851 | 6 | United International Pictures | false | false |
| 4 | 4 | Salt | $4,573 | -76.5% | 15 | - | $304 | $2,596,441 | 7 | Sony Pictures Releasing | false | false |
| 5 | 5 | The Book of Eli | $2,523 | -84% | 11 | - | $229 | $603,210 | 22 | Sony Pictures Releasing | false | false |
| 6 | - | The Losers | $2,486 | - | 1 | - | $2,486 | $148,097 | 16 | Warner Bros. | false | false |
| 7 | 9 | Prince of Persia: The Sands of Time | $392 | -36.3% | 1 | - | $392 | $4,104,340 | 16 | Walt Disney Pictures | false | false |
| 8 | - | When in Rome | $281 | - | 1 | - | $281 | $317,776 | 23 | Walt Disney Pictures | false | false |
