| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Despicable Me | $42,280 | - | 14 | - | $3,020 | $45,995 | 1 | United International Pictures | true | false |
| 2 | - | The Other Guys | $37,009 | - | 6 | - | $6,168 | $38,770 | 1 | Sony Pictures Releasing | true | false |
| 3 | 2 | Step Up 3D | $21,955 | -11% | 5 | - | $4,391 | $73,595 | 2 | N/A | false | false |
| 4 | 1 | The Expendables | $13,368 | -56.8% | 4 | - | $3,342 | $218,044 | 3 | N/A | false | false |
| 5 | - | The Ghost Writer | $6,996 | - | 3 | - | $2,332 | $6,996 | 1 | N/A | true | false |
| 6 | 4 | Cats & Dogs: The Revenge of Kitty Galore | $6,578 | -49.2% | 4 | -1 | $1,644 | $47,402 | 3 | Warner Bros. | false | false |
| 7 | 3 | Scott Pilgrim vs. the World | $6,509 | -53.4% | 3 | - | $2,169 | $43,214 | 2 | United International Pictures | false | false |
| 8 | 6 | Inception | $4,747 | -28.4% | 3 | -1 | $1,582 | $458,140 | 7 | Warner Bros. | false | false |
| 9 | 5 | Salt | $4,109 | -55.6% | 3 | -1 | $1,369 | $166,788 | 4 | Sony Pictures Releasing | false | false |
| 10 | 7 | Letters to Juliet | $3,328 | -43.1% | 1 | -2 | $3,328 | $41,392 | 3 | N/A | false | false |
| 11 | 8 | Shrek Forever After | $1,914 | -59.1% | 3 | -4 | $638 | $289,289 | 8 | United International Pictures | false | false |
| 12 | 13 | Toy Story 3 | $1,745 | -19.6% | 3 | +1 | $581 | $419,725 | 12 | Walt Disney Pictures | false | false |
| 13 | 12 | The Last Airbender | $1,386 | -49.8% | 2 | -2 | $693 | $58,578 | 4 | United International Pictures | false | false |
| 14 | 11 | The Human Centipede (First Sequence) | $1,248 | -59% | 1 | - | $1,248 | $7,900 | 2 | N/A | false | false |
| 15 | 10 | The Karate Kid | $1,023 | -68% | 1 | -2 | $1,023 | $135,418 | 6 | Sony Pictures Releasing | false | false |
| 16 | 9 | Vampires Suck | $924 | -76.1% | 2 | -1 | $462 | $21,345 | 3 | 20th Century Fox International | false | false |
| 17 | 14 | The Sorcerer's Apprentice | $831 | -40.9% | 3 | +1 | $277 | $87,240 | 5 | Walt Disney Pictures | false | false |
| 18 | 15 | The Ugly Duckling and Me! | $190 | -69% | 1 | -1 | $190 | $8,037 | 5 | N/A | false | false |
