| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 2 | Piranha 3D | $91,684 | +14.7% | 49 | - | $1,871 | $589,901 | 3 | N/A | false | false |
| 2 | - | Going the Distance | $89,560 | - | 45 | - | $1,990 | $89,560 | 1 | Warner Bros. | true | false |
| 3 | - | The American | $70,051 | - | 20 | - | $3,502 | $70,051 | 1 | N/A | true | false |
| 4 | 1 | Machete | $52,722 | -56.8% | 50 | - | $1,054 | $216,558 | 2 | N/A | false | false |
| 5 | 7 | Moskva, ya lyublyu tebya! | $38,992 | +26.5% | 36 | - | $1,083 | $126,981 | 2 | N/A | false | false |
| 6 | - | The Killer Inside Me | $32,854 | - | 30 | - | $1,095 | $32,854 | 1 | N/A | true | false |
| 7 | 3 | A Turtle's Tale: Sammy's Adventures | $27,178 | -50.3% | 42 | - | $647 | $309,610 | 4 | N/A | false | false |
| 8 | 4 | Avatar | $26,935 | -34.2% | 7 | -6 | $3,847 | $8,327,150 | 39 | 20th Century Fox International | false | false |
| 9 | 5 | The Switch | $20,256 | -41.6% | 40 | - | $506 | $265,714 | 3 | N/A | false | false |
| 10 | 8 | Step Up 3D | $17,767 | -40.8% | 18 | -5 | $987 | $475,915 | 5 | N/A | false | false |
| 11 | 6 | Inception | $17,669 | -45.3% | 21 | -7 | $841 | $1,405,404 | 8 | Warner Bros. | false | false |
| 12 | 11 | The Karate Kid | $10,652 | -46% | 36 | -7 | $295 | $301,808 | 4 | Sony Pictures Releasing | false | false |
| 13 | 9 | The Expendables | $8,814 | -69.6% | 50 | -16 | $176 | $1,063,359 | 5 | N/A | false | false |
| 14 | 14 | Cats & Dogs: The Revenge of Kitty Galore | $5,066 | -19.7% | 19 | -6 | $266 | $509,998 | 7 | Warner Bros. | false | false |
| 15 | 12 | Grown Ups | $3,196 | -76.8% | 20 | -20 | $159 | $695,685 | 6 | Sony Pictures Releasing | false | false |
| 16 | 15 | Tinker Bell and the Great Fairy Rescue | $2,585 | -50.2% | 21 | -12 | $123 | $79,982 | 5 | Walt Disney Pictures | false | false |
| 17 | 17 | Despicable Me | $1,471 | -43.8% | 7 | -5 | $210 | $1,098,658 | 9 | Universal Pictures International (UPI) | false | false |
| 18 | 13 | Salt | $1,241 | -83% | 19 | -23 | $65 | $1,241,634 | 7 | Sony Pictures Releasing | false | false |
| 19 | 16 | The Sorcerer's Apprentice | $570 | -83.5% | 6 | -9 | $95 | $1,230,364 | 8 | Walt Disney Pictures | false | false |
| 20 | 18 | The Twilight Saga: Eclipse | $276 | -83.9% | 2 | -2 | $138 | $1,686,533 | 10 | N/A | false | false |
| 21 | 22 | Predators | $53 | -71.8% | 1 | - | $53 | $397,314 | 10 | 20th Century Fox International | false | false |
