| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Resident Evil: Afterlife | $613,370 | -22.5% | 129 | +4 | $4,754 | $1,713,310 | 2 | Sony Pictures Releasing | false | false |
| 2 | 2 | The Last Airbender | $276,400 | -19.3% | 113 | - | $2,446 | $2,890,571 | 4 | United International Pictures | false | false |
| 3 | 3 | Inception | $86,679 | -31.1% | 43 | -35 | $2,015 | $2,835,754 | 7 | Warner Bros. | false | false |
| 4 | - | Going the Distance | $85,832 | - | 40 | - | $2,145 | $85,832 | 1 | Warner Bros. | true | false |
| 5 | 12 | Cats & Dogs: The Revenge of Kitty Galore | $47,790 | +848.8% | 47 | -13 | $1,016 | $1,953,150 | 6 | Warner Bros. | false | false |
| 6 | 4 | Oceans | $38,190 | -25.7% | 37 | +4 | $1,032 | $484,229 | 5 | Cine Colombia | false | false |
| 7 | - | From Paris with Love | $33,613 | - | 28 | - | $1,200 | $33,613 | 1 | - | true | false |
| 8 | - | The Box | $31,189 | - | 20 | - | $1,559 | $31,189 | 1 | Cine Colombia | true | false |
| 9 | 6 | Despicable Me | $27,799 | +10.5% | 48 | -7 | $579 | $2,681,084 | 8 | Universal Pictures International (UPI) | false | false |
| 10 | 5 | Grown Ups | $24,454 | -49.7% | 21 | -16 | $1,164 | $888,904 | 7 | Sony Pictures Releasing | false | false |
| 11 | - | The Burning Plain | $19,045 | - | 10 | - | $1,904 | $19,045 | 1 | Cine Colombia | true | false |
| 12 | 7 | Vampires Suck | $14,109 | -36% | 18 | -3 | $783 | $108,336 | 3 | 20th Century Fox International | false | false |
| 13 | 10 | Shrek Forever After | $10,142 | +2.7% | 13 | -4 | $780 | $6,769,458 | 11 | United International Pictures | false | false |
| 14 | 14 | Green Zone 2010 Re-release | $7,674 | +195.5% | 9 | - | $852 | $107,959 | 5 | United International Pictures | false | false |
| 15 | 9 | Daybreakers | $7,544 | -35.7% | 11 | -21 | $685 | $99,169 | 3 | Venus | false | false |
| 16 | 8 | Halloween II | $5,894 | -57.5% | 9 | -10 | $654 | $96,892 | 4 | Cine Colombia | false | false |
| 17 | 11 | Predators | $2,220 | -69.9% | 6 | -12 | $370 | $515,270 | 6 | 20th Century Fox International | false | false |
| 18 | 16 | The Sorcerer's Apprentice | $1,656 | -18.8% | 2 | -6 | $828 | $2,953,007 | 10 | Walt Disney Pictures | false | false |
| 19 | 13 | Horn of Plenty 2010 Re-release | $846 | -82.4% | 2 | -3 | $423 | $25,106 | 3 | Cineplex | false | false |
| 20 | 15 | Cherry Blossoms | $666 | -73.9% | 1 | -4 | $666 | $122,314 | 11 | Cine Colombia | false | false |
