| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 2 | Inception | $47,182 | +3.3% | 6 | -1 | $7,863 | $710,191 | 10 | Warner Bros. | false | false |
| 2 | - | Despicable Me | $38,912 | - | 8 | - | $4,864 | $38,912 | 1 | United International Pictures | true | false |
| 3 | 1 | The Sorcerer's Apprentice | $37,765 | -40.1% | 8 | - | $4,720 | $141,072 | 3 | Walt Disney Pictures | false | false |
| 4 | - | The Other Guys | $31,310 | - | 5 | - | $6,262 | $31,310 | 1 | Sony Pictures Releasing | true | false |
| 5 | 3 | Cats & Dogs: The Revenge of Kitty Galore | $15,350 | -37.8% | 6 | - | $2,558 | $48,123 | 2 | Warner Bros. | false | false |
| 6 | 5 | Grown Ups | $10,365 | -22.9% | 3 | -2 | $3,455 | $148,905 | 7 | Sony Pictures Releasing | false | false |
| 7 | 4 | Predators | $10,205 | -43.2% | 5 | - | $2,041 | $47,455 | 4 | 20th Century Fox International | false | false |
| 8 | 10 | Knight and Day 2010 Re-release | $8,085 | +44.6% | 1 | - | $8,085 | $430,209 | 12 | 20th Century Fox International | false | false |
| 9 | 7 | Salt | $6,926 | -27.1% | 1 | -2 | $6,926 | $306,841 | 9 | Sony Pictures Releasing | false | false |
| 10 | 9 | Toy Story 3 | $5,721 | +1% | 1 | -1 | $5,721 | $429,816 | 14 | Walt Disney Pictures | false | false |
| 11 | 6 | The Losers | $5,053 | -53.6% | 5 | - | $1,010 | $26,475 | 3 | Warner Bros. | false | false |
| 12 | 8 | The Last Airbender | $1,791 | -80.5% | 2 | -2 | $895 | $192,288 | 9 | United International Pictures | false | false |
| 13 | 12 | Shrek Forever After | $183 | -85.4% | 1 | -7 | $183 | $253,755 | 12 | United International Pictures | false | false |
| 14 | 11 | The Twilight Saga: Eclipse | $132 | -96% | 1 | -1 | $132 | $445,207 | 11 | - | false | false |
