| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Vampires Suck | $2,483,735 | - | - | - | - | $2,483,735 | 1 | 20th Century Fox International | true | false |
| 2 | - | Eat Pray Love | $1,643,930 | - | 320 | - | $5,137 | $1,645,354 | 1 | Sony Pictures Releasing | true | false |
| 3 | - | Sharm el Sheikh - Un'estate indimenticabile | $1,637,473 | - | - | - | - | $1,637,473 | 1 | Medusa Distribuzione | true | false |
| 4 | 2 | Resident Evil: Afterlife | $1,225,383 | -28.1% | 308 | +26 | $3,978 | $4,061,917 | 2 | Sony Pictures Releasing | false | false |
| 5 | 1 | Shrek Forever After | $1,158,495 | -39.5% | - | - | - | $20,976,661 | 4 | United International Pictures | false | false |
| 6 | 3 | The Solitude of Prime Numbers | $1,010,670 | -12.1% | - | - | - | $2,981,337 | 2 | Medusa Distribuzione | false | false |
| 7 | - | Cats & Dogs: The Revenge of Kitty Galore | $805,690 | - | - | - | - | $805,690 | 1 | Warner Bros. | true | false |
| 8 | - | Leaves of Grass | $429,662 | - | - | - | - | $429,662 | 1 | Eagle Pictures | true | false |
| 9 | 5 | Law Abiding Citizen | $389,437 | -36.4% | - | - | - | $5,766,365 | 4 | N/A | false | false |
| 10 | 4 | The American | $365,271 | -43.7% | - | - | - | $1,333,669 | 2 | United International Pictures | false | false |
| 11 | 9 | Somewhere | $355,667 | -13.1% | - | - | - | $2,121,985 | 3 | Medusa Distribuzione | false | false |
| 12 | - | Niente paura | $282,386 | - | - | - | - | $287,431 | 1 | N/A | true | false |
| 13 | 6 | The Expendables | $268,923 | -54.4% | - | - | - | $3,675,869 | 3 | 01 Distribution | false | false |
| 14 | 8 | The Sorcerer's Apprentice | $219,184 | -52.4% | - | - | - | $9,216,872 | 5 | Walt Disney Pictures | false | false |
| 15 | 7 | The Karate Kid | $167,741 | -67.2% | 118 | -225 | $1,421 | $2,531,278 | 3 | Sony Pictures Releasing | false | false |
| 16 | 13 | 20 Cigarettes | $49,546 | -2.4% | - | - | - | $171,279 | 2 | Istituto Luce | false | false |
| 17 | 19 | London River 2010 Re-release | $24,516 | +10.9% | - | - | - | $242,967 | 4 | BIM Distribuzione | false | false |
| 18 | 16 | Howl | $19,813 | -19.9% | - | - | - | $238,916 | 4 | Fandango | false | false |
| 19 | 10 | A Nightmare on Elm Street | $17,569 | -89.5% | - | - | - | $2,561,703 | 4 | Warner Bros. | false | false |
| 20 | 18 | Toy Story 3 | $17,557 | -22.7% | - | - | - | $17,717,188 | 11 | Walt Disney Pictures | false | false |
