| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Grown Ups | $12,062 | -20% | 7 | - | $1,723 | $32,529 | 2 | Sony Pictures Releasing | false | false |
| 2 | 2 | The Woman with a Broken Nose | $7,603 | -15.6% | 6 | - | $1,267 | $59,978 | 3 | N/A | false | false |
| 3 | 4 | Despicable Me | $5,811 | -7.9% | 6 | - | $968 | $15,770 | 2 | United International Pictures | false | false |
| 4 | 3 | The Expendables | $5,354 | -33.1% | 5 | - | $1,070 | $100,526 | 4 | N/A | false | false |
| 5 | - | Machete | $5,323 | - | 3 | - | $1,774 | $6,161 | 1 | N/A | true | false |
| 6 | - | Charlie St. Cloud | $3,641 | - | 5 | - | $728 | $4,281 | 1 | United International Pictures | true | false |
| 7 | 5 | The Karate Kid | $3,200 | -41.8% | 7 | - | $457 | $25,253 | 3 | Sony Pictures Releasing | false | false |
| 8 | 6 | Inception | $2,669 | +16.7% | 6 | - | $444 | $135,862 | 9 | Warner Bros. | false | false |
| 9 | - | The Killer Inside Me | $1,789 | - | 1 | - | $1,789 | $2,135 | 1 | N/A | true | false |
| 10 | 7 | Shrek Forever After | $1,786 | -10.7% | 7 | - | $255 | $167,307 | 17 | United International Pictures | false | false |
| 11 | 11 | Killers | $1,443 | +39.8% | 3 | - | $481 | $72,358 | 11 | N/A | false | false |
| 12 | 12 | Cats & Dogs: The Revenge of Kitty Galore | $1,234 | +30% | 9 | - | $137 | $29,082 | 7 | Warner Bros. | false | false |
| 13 | 10 | Letters to Juliet | $1,197 | -15.4% | 4 | - | $299 | $19,826 | 5 | N/A | false | false |
| 14 | 13 | Toy Story 3 | $1,190 | +47.1% | 7 | - | $170 | $71,404 | 14 | Walt Disney Pictures | false | false |
| 15 | 8 | The Last Airbender | $978 | -43.8% | 6 | - | $163 | $45,302 | 5 | United International Pictures | false | false |
| 16 | 15 | Sex and the City 2 | $761 | +30.8% | 9 | - | $84 | $370,160 | 16 | Warner Bros. | false | false |
| 17 | 9 | Salt | $721 | -56.1% | 7 | - | $103 | $71,556 | 7 | Sony Pictures Releasing | false | false |
| 18 | 17 | Prince of Persia: The Sands of Time | $513 | -1.5% | 6 | - | $85 | $154,832 | 16 | Walt Disney Pictures | false | false |
| 19 | 20 | A Nightmare on Elm Street | $415 | +19.6% | 6 | - | $69 | $61,043 | 14 | Warner Bros. | false | false |
| 20 | 14 | The Twilight Saga: Eclipse | $383 | -49.5% | 5 | - | $76 | $94,283 | 12 | N/A | false | false |
| 21 | 19 | Knight and Day 2010 Re-release | $254 | -26.8% | 7 | - | $36 | $35,701 | 8 | 20th Century Fox International | false | false |
| 22 | 18 | Predators | $247 | -49% | 7 | - | $35 | $28,267 | 6 | 20th Century Fox International | false | false |
| 23 | 22 | Get Him to the Greek | $110 | +96.4% | 4 | - | $27 | $14,659 | 9 | United International Pictures | false | false |
| 24 | 21 | When You're Strange | $106 | -64.3% | 1 | - | $106 | $9,702 | 8 | N/A | false | false |
| 25 | 16 | The Sorcerer's Apprentice | $76 | -86.9% | 4 | - | $19 | $52,660 | 10 | United International Pictures | false | false |
