| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Twilight Saga: Eclipse | $51,184 | - | 10 | - | $5,118 | $51,184 | 1 | - | true | false |
| 2 | 1 | Resident Evil: Afterlife | $37,782 | -38.8% | 16 | - | $2,361 | $273,060 | 3 | Sony Pictures Releasing | false | false |
| 3 | 15 | Piranha 3D | $16,590 | +3,594.9% | 4 | +3 | $4,147 | $17,652 | 2 | - | false | false |
| 4 | 3 | Cats & Dogs: The Revenge of Kitty Galore | $12,781 | -13.6% | 7 | -3 | $1,825 | $253,747 | 6 | Warner Bros. | false | false |
| 5 | - | Wall Street: Money Never Sleeps | $10,751 | - | 5 | - | $2,150 | $10,751 | 1 | 20th Century Fox International | true | false |
| 6 | 2 | The Last Airbender | $10,645 | -42.6% | 11 | - | $967 | $226,424 | 5 | Paramount Pictures International | false | false |
| 7 | 4 | Going the Distance | $6,034 | -26.6% | 4 | - | $1,508 | $19,706 | 2 | Warner Bros. | false | false |
| 8 | 6 | Igor | $5,780 | +12% | 3 | -1 | $1,926 | $15,916 | 3 | - | false | false |
| 9 | 5 | Grown Ups | $5,284 | -23.5% | 5 | - | $1,056 | $135,769 | 7 | Sony Pictures Releasing | false | false |
| 10 | 9 | Despicable Me | $2,019 | -18.3% | 4 | -3 | $504 | $266,211 | 9 | Universal Pictures International (UPI) | false | false |
| 11 | 11 | The Forbidden Kingdom 2010 Re-release | $1,342 | -29.8% | 2 | +1 | $671 | $4,224 | 2 | - | false | false |
| 12 | 7 | Inception | $1,146 | -67% | 3 | -1 | $382 | $161,622 | 8 | Warner Bros. | false | false |
| 13 | 8 | Letters to Juliet | $452 | -83.1% | 1 | -3 | $452 | $11,575 | 3 | - | false | false |
| 14 | 10 | Salt | $420 | -79.9% | 2 | -3 | $210 | $84,397 | 6 | Sony Pictures Releasing | false | false |
| 15 | 14 | Love Happens | $323 | -64.6% | 2 | - | $161 | $1,978 | 2 | - | false | false |
