Italian 2010 Weekend 38
September 23-26, 2010
Key:New This Week
| Rank | LW | Release | Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | - | Inception | $3,556,167 | - | 578 | - | $6,152 | $3,557,432 | 1 | Warner Bros. |
| 2 | - | The Last Airbender | $2,954,554 | - | 428 | - | $6,903 | $2,954,554 | 1 | United International Pictures |
| 3 | 1 | Vampires Suck | $1,332,922 | -46.3% | 296 | - | $4,503 | $4,676,584 | 2 | 20th Century Fox International |
| 4 | - | La passione di Laura | $1,070,857 | - | - | - | - | $1,093,799 | 1 | 01 Distribution |
| 5 | 2 | Eat Pray Love | $1,052,299 | -36% | 320 | - | $3,288 | $3,583,444 | 2 | Sony Pictures Releasing |
| 6 | 3 | Sharm el Sheikh - Un'estate indimenticabile | $976,145 | -40.4% | 291 | - | $3,354 | $3,261,205 | 2 | Medusa Distribuzione |
| 7 | 6 | The Solitude of Prime Numbers | $456,493 | -54.8% | 234 | - | $1,950 | $3,998,872 | 3 | Medusa Distribuzione |
| 8 | 5 | Shrek Forever After | $427,409 | -63.1% | 200 | - | $2,137 | $22,380,036 | 5 | United International Pictures |
| 9 | 7 | Cats & Dogs: The Revenge of Kitty Galore | $411,427 | -48.9% | 261 | - | $1,576 | $1,417,202 | 2 | Warner Bros. |
| 10 | 4 | Resident Evil: Afterlife | $408,564 | -66.7% | 180 | -128 | $2,269 | $5,173,291 | 3 | Sony Pictures Releasing |
| 11 | 9 | Law Abiding Citizen | $171,726 | -55.9% | 67 | - | $2,563 | $6,293,218 | 5 | N/A |
| 12 | 8 | Leaves of Grass | $166,182 | -61.3% | 136 | - | $1,221 | $806,549 | 2 | Eagle Pictures |
| 13 | 11 | Somewhere | $138,479 | -61.1% | 75 | - | $1,846 | $2,475,442 | 4 | Medusa Distribuzione |
| 14 | 12 | Niente paura | $75,797 | -73.2% | - | - | - | $528,959 | 2 | N/A |
| 15 | 13 | The Expendables | $45,249 | -83.2% | 36 | - | $1,256 | $3,967,039 | 4 | 01 Distribution |
| 16 | - | Wind with the Gone | $44,311 | - | - | - | - | $76,419 | 1 | N/A |
| 17 | 10 | The American | $38,818 | -89.4% | 36 | - | $1,078 | $1,543,799 | 3 | United International Pictures |
| 18 | 14 | The Sorcerer's Apprentice | $36,646 | -83.3% | 36 | - | $1,017 | $9,617,535 | 6 | Walt Disney Pictures |
| 19 | 15 | The Karate Kid | $30,871 | -81.6% | 32 | -86 | $964 | $2,702,998 | 4 | Sony Pictures Releasing |
| 20 | 16 | 20 Cigarettes | $20,947 | -57.7% | 21 | - | $997 | $224,266 | 3 | Istituto Luce |
| 21 | 20 | Toy Story 3 | $13,795 | -21.4% | 14 | - | $985 | $17,399,390 | 12 | Walt Disney Pictures |
| 22 | 17 | London River 2010 Re-release | $13,430 | -45.2% | 11 | - | $1,220 | $262,440 | 5 | BIM Distribuzione |
| 23 | - | The Secret in Their Eyes | $10,868 | - | 8 | - | $1,358 | $1,388,908 | 17 | Lucky Red |
| 24 | 18 | Howl | $10,277 | -48.1% | 10 | - | $1,027 | $257,982 | 5 | Fandango |
| 25 | - | Basilicata Coast to Coast | $7,692 | - | 5 | - | $1,538 | $4,273,398 | 25 | Eagle Pictures |
| 26 | - | Miral | $6,726 | - | 9 | - | $747 | $231,770 | 4 | Eagle Pictures |
| 27 | - | My Son, My Son, What Have Ye Done | $5,371 | - | 8 | - | $671 | $39,842 | 3 | N/A |
| 28 | - | North Face | $2,947 | - | 2 | - | $1,473 | $110,547 | 5 | N/A |
| 29 | - | Marmaduke | $2,859 | - | 5 | - | $571 | $2,475,407 | 7 | 20th Century Fox International |
| 30 | - | Departures | $2,576 | - | 2 | - | $1,288 | $858,318 | 25 | N/A |
