| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Despicable Me | $61,868 | - | 8 | - | $7,733 | $61,868 | 1 | United International Pictures | true | false |
| 2 | 1 | Step Up 3D | $60,578 | -33.8% | 8 | - | $7,572 | $393,449 | 3 | Jaguar Film International Distribution | false | false |
| 3 | - | Wall Street: Money Never Sleeps | $28,588 | - | 7 | - | $4,084 | $28,588 | 1 | 20th Century Fox International | true | false |
| 4 | 2 | Piranha 3D | $22,936 | -34.4% | 7 | -1 | $3,276 | $178,307 | 3 | Italian International Film | false | false |
| 5 | 4 | Dinner for Schmucks | $19,914 | -37.4% | 7 | - | $2,844 | $68,517 | 2 | United International Pictures | false | false |
| 6 | 3 | The Other Guys | $14,805 | -54.5% | 6 | - | $2,467 | $61,797 | 2 | Sony Pictures Releasing | false | false |
| 7 | 5 | The Expendables | $14,667 | -46.6% | 6 | - | $2,444 | $154,411 | 3 | N/A | false | false |
| 8 | - | You Again | $12,820 | - | 5 | - | $2,564 | $12,820 | 1 | Walt Disney Pictures | true | false |
| 9 | 6 | Cats & Dogs: The Revenge of Kitty Galore | $9,490 | -55% | 5 | -5 | $1,898 | $100,097 | 3 | Warner Bros. | false | false |
| 10 | 9 | Grown Ups | $7,664 | -27.1% | 4 | -1 | $1,916 | $237,563 | 7 | Sony Pictures Releasing | false | false |
| 11 | 7 | Charlie St. Cloud | $6,889 | -52.4% | 7 | - | $984 | $66,633 | 3 | United International Pictures | false | false |
| 12 | 8 | Inception | $6,817 | -51.3% | 4 | -4 | $1,704 | $548,036 | 9 | Warner Bros. | false | false |
| 13 | 12 | 4.3.2.1. | $1,724 | -38.9% | 1 | -1 | $1,724 | $15,841 | 3 | Prime Pictures | false | false |
| 14 | 13 | Knight and Day 2010 Re-release | $1,421 | -29.7% | 2 | - | $710 | $262,553 | 13 | 20th Century Fox International | false | false |
| 15 | 21 | 12 Angry Lebanese: The Documentary | $1,421 | +169.6% | 1 | - | $1,421 | $19,475 | 4 | N/A | false | false |
| 16 | 17 | The Sorcerer's Apprentice | $1,147 | -1.4% | 2 | - | $573 | $188,265 | 11 | Walt Disney Pictures | false | false |
| 17 | 11 | Salt | $1,074 | -64.7% | 2 | -1 | $537 | $492,627 | 10 | Sony Pictures Releasing | false | false |
| 18 | 15 | Partir | $1,067 | -15.1% | 3 | +1 | $355 | $12,796 | 4 | Italian International Film | false | false |
| 19 | 10 | La Tarajo3 La Esteslam | $1,003 | -77.3% | 1 | -4 | $1,003 | $39,797 | 3 | N/A | false | false |
| 20 | 16 | Triage | $824 | -31.8% | 3 | -1 | $274 | $2,684 | 2 | N/A | false | false |
| 21 | 20 | The Fourth Kind | $650 | +17.8% | 2 | - | $325 | $29,322 | 6 | N/A | false | false |
| 22 | 18 | Lembi 8 Giga | $500 | -48.9% | 1 | - | $500 | $211,483 | 10 | N/A | false | false |
| 23 | 22 | The Joneses | $495 | -3.5% | 1 | -2 | $495 | $40,661 | 5 | Italian International Film | false | false |
| 24 | 19 | Leap Year | $273 | -51.8% | 1 | - | $273 | $36,110 | 7 | N/A | false | false |
