| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Resident Evil: Afterlife | $19,448 | - | 8 | - | $2,431 | $19,448 | 1 | Sony Pictures Releasing | true | false |
| 2 | 1 | Grown Ups | $6,967 | -42.2% | 7 | - | $995 | $43,654 | 3 | Sony Pictures Releasing | false | false |
| 3 | 2 | The Woman with a Broken Nose | $6,783 | -10.8% | 6 | - | $1,130 | $72,254 | 4 | N/A | false | false |
| 4 | 8 | Inception | $4,388 | +64.4% | 6 | - | $731 | $143,107 | 10 | Warner Bros. | false | false |
| 5 | 3 | Despicable Me | $4,355 | -25.1% | 6 | - | $725 | $21,960 | 3 | United International Pictures | false | false |
| 6 | 4 | The Expendables | $3,638 | -32.1% | 5 | - | $727 | $106,843 | 5 | N/A | false | false |
| 7 | 5 | Machete | $3,545 | -33.4% | 3 | - | $1,181 | $12,932 | 2 | N/A | false | false |
| 8 | 6 | Charlie St. Cloud | $2,567 | -29.5% | 5 | - | $513 | $8,525 | 2 | United International Pictures | false | false |
| 9 | 7 | The Karate Kid | $1,894 | -40.8% | 7 | - | $270 | $27,552 | 4 | Sony Pictures Releasing | false | false |
| 10 | 11 | Killers | $1,544 | +7% | 3 | - | $514 | $74,426 | 12 | N/A | false | false |
| 11 | 9 | The Killer Inside Me | $1,199 | -33% | 1 | - | $1,199 | $4,110 | 2 | N/A | false | false |
| 12 | 13 | Letters to Juliet | $1,189 | -0.7% | 4 | - | $297 | $21,889 | 6 | N/A | false | false |
| 13 | 17 | Salt | $910 | +26.2% | 6 | -1 | $151 | $73,157 | 8 | Sony Pictures Releasing | false | false |
| 14 | 12 | Cats & Dogs: The Revenge of Kitty Galore | $729 | -40.9% | 9 | - | $81 | $30,120 | 8 | Warner Bros. | false | false |
| 15 | 15 | The Last Airbender | $535 | -45.3% | 6 | - | $89 | $46,460 | 6 | United International Pictures | false | false |
| 16 | 19 | A Nightmare on Elm Street | $274 | -34% | 6 | - | $45 | $61,670 | 15 | Warner Bros. | false | false |
| 17 | 22 | Predators | $190 | -23.1% | 7 | - | $27 | $28,761 | 7 | 20th Century Fox International | false | false |
| 18 | 21 | Knight and Day 2010 Re-release | $183 | -28% | 7 | - | $26 | $36,257 | 9 | 20th Century Fox International | false | false |
| 19 | 20 | The Twilight Saga: Eclipse | $132 | -65.5% | 5 | - | $26 | $94,738 | 13 | N/A | false | false |
| 20 | 24 | When You're Strange | $103 | -2.8% | 1 | - | $103 | $9,957 | 9 | N/A | false | false |
